Interactions Between Medications and Supplements: Can You Combine Red Yeast Rice and CoQ10? - Pharmacology

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Interactions between medications and dietary supplements?


Hello, I would like to inquire if it is safe to additionally supplement with red yeast rice or Coenzyme Q10 while I am currently taking the medications "Hengmai Xun," "Yizhi Ke," and "Boki."

wei, 30~39 year old female. Ask Date: 2022/08/01

Dr. Huang Shenggang reply Pharmacology


Hello Wei: Thank you for your inquiry.
The indications for Hengmai include angina pectoris and hypertension; Yizhi is indicated for primary hypercholesterolemia and primary mixed dyslipidemia.
For the prevention of coronary heart disease patients, it is used after percutaneous transluminal coronary angioplasty (PTCA) to reduce major cardiovascular adverse events (such as cardiac death, non-fatal myocardial infarction, and coronary revascularization).
The indications for Borki include the prevention of myocardial infarction, prevention of thromboembolic disease, and transient ischemic attacks.
Red yeast rice is classified as a food product, and some products have passed the Ministry of Health and Welfare's health food certification, which can effectively regulate lipid levels.
Additionally, coenzyme Q10 is a fat-soluble nutrient classified as a food.
It is not recommended to use red yeast rice (with health food certification) and Yizhi simultaneously! There is a significant difference between health foods and dietary supplements! Health foods must undergo scientific research and demonstrate data showing they promote public health and reduce the risk of disease.
They must also obtain a health food registration permit issued by the Ministry of Health and Welfare (referred to as MOHW), and the product packaging must bear the small green person logo and approved efficacy claims to be classified as health food.
Conversely, "dietary supplements" that do not have the national small green person logo certification are essentially regular foods and can only serve as nutritional supplements.

Reply Date: 2022/08/01

More Info


When considering the combination of medications and dietary supplements, it is essential to understand the potential interactions and effects on health. In your case, you are currently taking "恆脈循" (Hengmaixun), "益脂可" (Yizhi Ke), and "伯基" (Bojie), and you are interested in adding red yeast rice and CoQ10 (Coenzyme Q10) to your regimen.


Understanding the Medications
1. 恆脈循 (Hengmaixun): This medication is typically used for conditions like angina and hypertension. It may contain active ingredients that help improve blood flow and reduce heart strain.


2. 益脂可 (Yizhi Ke): This is often prescribed for managing cholesterol levels and may contain statin-like compounds that help lower cholesterol and triglycerides.

3. 伯基 (Bojie): This medication is used to prevent myocardial infarction and thromboembolic events, indicating it has cardiovascular protective properties.


Red Yeast Rice
Red yeast rice is a traditional Chinese food product that contains monacolin K, which is chemically identical to the active ingredient in the statin drug lovastatin. It is often used as a natural supplement to help lower cholesterol levels. However, because it acts similarly to statins, combining it with other statin medications (like those in 益脂可) can increase the risk of side effects, particularly muscle-related issues such as myopathy or rhabdomyolysis.


CoQ10 (Coenzyme Q10)
CoQ10 is a fat-soluble antioxidant that plays a crucial role in energy production within cells. It is often recommended for individuals taking statins because statins can deplete CoQ10 levels in the body. Supplementing with CoQ10 may help mitigate some of the muscle-related side effects associated with statin use.


Potential Interactions
1. Red Yeast Rice and 益脂可: Given that both red yeast rice and 益脂可 may lower cholesterol and have similar mechanisms of action, taking them together could lead to an increased risk of side effects. It is generally advised to avoid this combination unless under strict medical supervision.

2. CoQ10 and Statins: CoQ10 is considered safe to take alongside statins and may even be beneficial. It can help replenish CoQ10 levels that might be reduced due to statin use, potentially alleviating muscle pain or weakness.


Recommendations
- Consult Your Healthcare Provider: Before adding red yeast rice or CoQ10 to your regimen, it is crucial to discuss it with your healthcare provider. They can provide personalized advice based on your overall health, the specific medications you are taking, and any other supplements you may be considering.

- Monitor for Side Effects: If you do decide to take these supplements, monitor your body for any unusual symptoms, especially muscle pain or weakness, which could indicate an adverse reaction.

- Consider Timing: If you are advised to take both red yeast rice and 益脂可, spacing them out (taking them at different times of the day) may help reduce the risk of interactions, but this should be done under medical guidance.


Conclusion
In summary, while CoQ10 can be a beneficial supplement for those taking statins, the combination of red yeast rice with medications like 益脂可 should be approached with caution due to the potential for increased side effects. Always prioritize communication with your healthcare provider to ensure safe and effective management of your health conditions.

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