Fatty Liver: Key Questions and Management Strategies - Gastroenterology and Hepatology

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Fatty liver disease issues?


Hello Doctor, last September when I had my blood drawn, my liver function was abnormal with GOT at 30 and GPT at 52.
During the ultrasound examination, the doctor mentioned that I had severe fatty liver (I think I heard the doctor mention cell death, but he didn't discuss it with me during the follow-up visit).
Over the next six months, I lost 7 kilograms, and my liver enzymes returned to normal (18/26).
However, in the past six months, I have regained about 3-4 kilograms, and my recent blood test results were (18/30), with triglycerides not showing any red flags.
I would like to ask the doctor the following questions:
1.
Does this mean that my liver is currently not inflamed?
2.
My fatty liver should still be moderate to severe, but if my liver is not inflamed, will simple fatty liver still lead to gradual fibrosis or cell death? Or is it that as long as there is no inflammation, different degrees of fatty liver are actually okay?
3.
The doctor who drew my blood said an ultrasound should be done every 2-3 years, but the doctor who performed the ultrasound suggested every six months.
How often should I schedule an ultrasound?
4.
Can an ultrasound detect liver fibrosis? The doctor who performed my ultrasound told me that he could not see any fibrosis or cell death.
Thank you, doctor.

Nìmíng, 20~29 year old female. Ask Date: 2022/08/05

Dr. Chen Shidian reply Gastroenterology and Hepatology


As long as the BMI is maintained within the normal range and liver function is normal, that is sufficient.

Reply Date: 2022/08/05

More Info


Understanding fatty liver disease and its management is crucial for maintaining liver health and preventing potential complications. Based on your situation, let’s address your questions and provide some insights into fatty liver disease, its implications, and management strategies.

1. Is my liver currently inflamed?
Your liver function tests (GOT and GPT) have returned to normal levels, which is a positive sign. Elevated liver enzymes typically indicate inflammation or damage to liver cells. Since your recent tests show normal enzyme levels, it suggests that there is likely no active inflammation in your liver at this time. However, it’s essential to continue monitoring your liver health through regular check-ups, as liver conditions can change over time.

2. Does fatty liver still pose a risk for fibrosis or cell death?
Fatty liver disease, even in the absence of inflammation, can still lead to complications over time. The presence of fat in liver cells can lead to a condition known as non-alcoholic fatty liver disease (NAFLD), which can progress to non-alcoholic steatohepatitis (NASH) if inflammation occurs. While your liver may not currently be inflamed, it is important to maintain a healthy lifestyle to prevent further fat accumulation. If fatty liver persists without inflammation, it may not lead to immediate fibrosis or cell death, but it can still pose risks if not managed properly. Regular monitoring and lifestyle modifications are key to preventing progression.

3. How often should I have ultrasounds?
The frequency of ultrasound examinations can vary based on individual circumstances and the recommendations of your healthcare provider. Generally, if you have a history of significant fatty liver disease, it is advisable to have follow-up ultrasounds every 6 to 12 months to monitor any changes in liver condition. Your healthcare provider may suggest a more tailored approach based on your overall health, weight changes, and liver function test results. It’s important to follow their guidance and communicate any concerns you may have.

4. Can ultrasounds detect fibrosis?
Standard abdominal ultrasounds can provide information about liver size and the presence of fatty deposits, but they are not definitive for assessing fibrosis or cellular death. More advanced imaging techniques, such as elastography (FibroScan) or MRI, can provide better insights into liver stiffness, which correlates with fibrosis. If there are concerns about fibrosis, discussing these advanced imaging options with your healthcare provider may be beneficial.


Management Strategies for Fatty Liver Disease
To effectively manage fatty liver disease and promote liver health, consider the following strategies:
- Weight Management: Since you have successfully lost weight, continue to focus on maintaining a healthy weight. Aim for gradual weight loss if you need to shed additional pounds, as rapid weight loss can sometimes exacerbate liver issues.

- Balanced Diet: Adopt a diet rich in whole foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats. Limit saturated fats, refined sugars, and processed foods. Foods high in omega-3 fatty acids (like fish, walnuts, and flaxseeds) can be beneficial for liver health.

- Regular Exercise: Engage in regular physical activity, aiming for at least 150 minutes of moderate-intensity exercise per week. This can help reduce liver fat and improve overall metabolic health.

- Avoid Alcohol and Toxins: Since alcohol can exacerbate liver damage, it’s advisable to avoid or limit alcohol consumption. Additionally, be cautious with medications and supplements that may affect liver function.

- Regular Monitoring: Keep up with regular check-ups, including liver function tests and imaging studies as recommended by your healthcare provider. This will help track your liver health and catch any potential issues early.

- Consult a Specialist: If you have concerns about your liver health or if your condition changes, consider consulting a hepatologist or a gastroenterologist who specializes in liver diseases for more tailored advice and management.

In conclusion, while your current liver function tests are normal, it’s essential to remain vigilant and proactive in managing your liver health through lifestyle changes and regular monitoring. By doing so, you can significantly reduce the risk of progression to more severe liver conditions.

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