Pregnancy Chances with Hormonal Medications for PCOS - Obstetrics and Gynecology

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Hello Doctor: I have polycystic ovary syndrome and recently started taking Yaz for the first time.
I took it daily until the 16th day when I started experiencing menstrual bleeding, so I stopped the medication and went to see a doctor (the thickness of the endometrium confirmed it was menstruation).
Three days later, I started taking a prescription medication consisting of 5 mg of Medroxyprogesterone and 0.625 mg of Estradiol, and after taking it for 7 days, I had sexual intercourse with my boyfriend.
Can you tell me if combining these two hormonal medications is equivalent to taking a contraceptive pill? What is the likelihood of pregnancy? Thank you! 🙏

Ms. Wu, 30~39 year old female. Ask Date: 2022/08/27

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, you should be in your safe period, so pregnancy is unlikely.
Those two types of medication do not have contraceptive effects.
You can consider taking birth control pills.
Wishing you good health.

Reply Date: 2022/08/27

More Info


When it comes to managing Polycystic Ovary Syndrome (PCOS) and understanding the implications of hormonal medications on pregnancy chances, it's essential to consider several factors, including the medications being used, the underlying condition, and individual health circumstances.

PCOS is a common endocrine disorder that can affect a woman's menstrual cycle, fertility, hormones, and appearance. Women with PCOS often experience irregular menstrual cycles and may have difficulty ovulating, which can lead to challenges in conceiving. However, with appropriate medical intervention, many women with PCOS can successfully conceive.

In your case, you mentioned starting a medication regimen that includes Medroxyprogesterone (often referred to as "Medrone") and conjugated estrogens (like "Esmond"). Medroxyprogesterone is a synthetic form of progesterone, which is often used to regulate menstrual cycles and support the uterine lining. Conjugated estrogens can help with hormonal balance.
1. Combination of Hormonal Medications: The combination of Medroxyprogesterone and conjugated estrogens does not function as a traditional contraceptive pill. Instead, it is often used to manage hormonal levels and regulate the menstrual cycle. While these medications can help in creating a more favorable environment for ovulation, they do not guarantee contraception. If you are actively trying to conceive, it's crucial to discuss your specific situation with your healthcare provider to understand how these medications may affect your chances of pregnancy.

2. Pregnancy Chances: The likelihood of becoming pregnant while on these medications depends on various factors, including the timing of ovulation, the health of your partner's sperm, and your overall reproductive health. If you have been taking these medications as prescribed and have had unprotected intercourse during your fertile window, there is a possibility of conception. However, if your cycles are irregular due to PCOS, predicting ovulation can be challenging.

3. Monitoring and Adjustments: It is essential to have regular follow-ups with your healthcare provider to monitor your response to the medications. They may recommend additional treatments or adjustments based on your menstrual cycle and ovulation patterns. For women with PCOS, lifestyle modifications such as maintaining a healthy weight, regular exercise, and a balanced diet can also significantly improve fertility outcomes.

4. Understanding Your Body: Since you experienced menstruation after stopping the medication, it indicates that your body is responding to the hormonal treatment. However, if you have concerns about your menstrual cycle or the effectiveness of the medications, it is advisable to consult with your healthcare provider. They may suggest further evaluations, such as hormone level testing or ultrasound examinations, to assess your ovarian function and uterine lining.

5. Emotional Support: Dealing with fertility issues can be emotionally taxing. It is essential to seek support from friends, family, or support groups. Many women find it helpful to connect with others who are experiencing similar challenges.

In conclusion, while hormonal medications can help manage PCOS and improve the chances of conception, they do not act as contraceptives. If you are trying to conceive, it is crucial to work closely with your healthcare provider to monitor your progress and make any necessary adjustments to your treatment plan. Remember, every woman's journey with PCOS is unique, and with the right support and treatment, many women can achieve their goal of pregnancy.

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