HPV 6 and Its Impact on Urological Health: A Patient's Guide - Urology

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HPV type 6 positive +++


Hello Dr.
Du,
In July, my girlfriend had an abnormal Pap smear showing CIN3 and underwent further HPV testing, which revealed HPV 6 and HPV 16 positivity, along with the presence of lesions.
She has already received laser treatment for HPV 6 and a cone biopsy for HPV 16, and is currently in recovery.
I also went to the urology department to receive the HPV vaccine, and the doctor recommended an HPV DNA test, which did not show any lesions.
In August, the HPV report indicated HPV 6 positivity.
The urologist mentioned that aside from receiving the 9-valent vaccine, there are no better treatment options available.

I have read in journals such as BMC and JAMA that the vaccine shows significant auxiliary treatment effects against the viruses it covers, although this seems to contradict the vaccine insert recommendations.

1.
For individuals with subclinical infections, after vaccination, if the currently infected subtype is cleared by the body's immune response, is the vaccine's protective efficacy null or low? Is there a need for a booster dose?
2.
Does receiving the vaccine reduce the likelihood of HPV 6 causing genital warts (GW)? How can the probability of GW occurrence be minimized?
I apologize for the lengthy message and appreciate your time in addressing my questions.

Xiao Fang, 20~29 year old female. Ask Date: 2022/08/29

Dr. Du Shixi reply Urology


Hello: Opinions in academic articles are not always comprehensive and should still be based on the product insert.
1.
Currently, there is no mention of booster vaccinations.
2.
The vaccine insert is currently focused on prevention; it is intended to prevent infections from certain types of viruses after administration, but it is not 100% effective.
The pharmaceutical companies and agencies have not certified it for treatment.
Wishing you good health.

Reply Date: 2022/08/29

More Info


Understanding HPV 6 and Its Impact on Urological Health: A Patient's Guide
Human Papillomavirus (HPV) is a group of more than 200 related viruses, of which HPV 6 and HPV 16 are notable for their association with various health issues, including genital warts (GW) and cervical cancer. Your situation, involving your girlfriend's diagnosis of CIN3 and your own HPV 6 positivity, raises important questions about the implications of these infections and the role of vaccination.

1. HPV Vaccination and Immune Response: The HPV vaccine, particularly the 9-valent vaccine (Gardasil 9), is designed to protect against several high-risk and low-risk HPV types, including HPV 6 and HPV 16. For individuals who are already infected with a specific HPV type, the vaccine does not clear the existing infection but can provide protection against other types of HPV. In the case of subclinical infections, if the body successfully clears the infection, the vaccine may still offer some level of protection against reinfection. However, the effectiveness of the vaccine in individuals with pre-existing infections is not fully established, and there is no current recommendation for booster doses specifically for those already infected.

2. Impact on Genital Warts: HPV 6 is known to cause genital warts, and while vaccination can help prevent new infections with HPV types covered by the vaccine, it does not treat existing infections. Therefore, if you are already infected with HPV 6, the vaccine will not reduce the likelihood of developing genital warts from that specific strain. To lower the probability of developing genital warts, it is crucial to maintain a healthy immune system, practice safe sex, and avoid skin-to-skin contact with warts. Regular follow-ups with a healthcare provider for monitoring and potential treatment of any lesions are also advisable.

3. Transmission and Cross-Infection: HPV is primarily transmitted through direct skin-to-skin contact, including sexual activities. Even in the absence of visible symptoms, it is possible to transmit the virus to a partner. If you have HPV 6, there is a risk of transmission to your partner, which could lead to them developing genital warts or other HPV-related conditions. It is essential to communicate openly with your partner about your HPV status and consider safe practices, such as using condoms, to reduce the risk of transmission.

4. Monitoring and Follow-Up: Given that your HPV report showed a high viral load for HPV 6, it is important to continue monitoring your health. Regular check-ups with your urologist or healthcare provider can help track any changes in your condition. If you notice any symptoms or changes, such as the appearance of warts, it is crucial to seek medical advice promptly.

5. Psychosocial Considerations: Dealing with an HPV diagnosis can be stressful for both you and your partner. It is important to seek support, whether through counseling, support groups, or educational resources, to help manage any anxiety or concerns related to HPV and its implications for your sexual health and relationships.

In summary, while the HPV vaccine is a valuable tool for preventing certain types of HPV infections, it does not treat existing infections. The best course of action is to maintain regular medical follow-ups, practice safe sex, and support each other through this process. If you have further questions or concerns, do not hesitate to reach out to your healthcare provider for personalized advice and guidance.

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