Are You Storing Eye Drops Correctly? Risks of Refrigeration Explained - Ophthalmology

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Questions about eye drops?


Hello, Doctor Gao.
I have allergies and chronic blepharitis, and I usually go to a general clinic to get antibiotic eye drops, such as Saline eye drops.
However, I often store the unused drops in the refrigerator.
I recently saw a news article stating: "Daily Must-See: Storing Medications in the Refrigerator Can Spoil Them Faster! Some Eye Drops Can Cause Blindness If Frozen" (August 21, 2022, @CTi News).
This has made me worried about potentially causing blindness due to my storage method, so I am here to ask for advice.
Thank you.

Awei, 30~39 year old female. Ask Date: 2022/09/09

Dr. Gao Pilin reply Ophthalmology


Hello, A-Wei: The narration in the video states that if eye drops are refrigerated, they may crystallize and potentially scratch the cornea.
It does not imply that it will cause blindness.
However, this situation is quite rare; for most eye drops, refrigeration is not an issue, so please rest assured.

Reply Date: 2022/09/09

More Info


When it comes to storing eye drops, particularly those used for conditions like allergies or chronic blepharitis, proper storage is crucial to ensure their efficacy and safety. Your concern about refrigerating eye drops is valid, especially in light of recent reports suggesting that certain medications may degrade faster when stored improperly.

Firstly, it's important to understand that not all eye drops are created equal. Some formulations are designed to be stored at room temperature, while others may require refrigeration. For instance, antibiotic eye drops, such as those you mentioned (like "Saline Eye Drops"), typically have specific storage instructions provided by the manufacturer. If the label indicates that refrigeration is not necessary, storing them in the fridge could potentially alter their chemical composition, leading to reduced effectiveness or even harmful effects.

The primary concern with refrigerating eye drops is that freezing temperatures can cause the solution to crystallize or separate, which may render the medication ineffective. Additionally, some preservatives used in eye drops can become unstable at lower temperatures, leading to potential irritation or adverse reactions when applied to the eye. In extreme cases, using improperly stored eye drops could lead to serious complications, including infections or damage to the eye, which could contribute to vision loss.

For eye drops that do require refrigeration, it is essential to ensure that they are kept at a consistent temperature and not subjected to freezing. If you have any doubts about the appropriate storage conditions for your specific eye drops, it is best to consult your pharmacist or healthcare provider for guidance.

Moreover, if you have been storing your eye drops in the refrigerator and are concerned about their safety, it would be wise to check the expiration date and inspect the drops for any changes in appearance or consistency before using them. If you notice any unusual changes, it is advisable to discard the drops and obtain a new prescription.

In addition to proper storage, it's also crucial to practice good hygiene when using eye drops. Always wash your hands before applying the drops, avoid touching the dropper tip to any surface (including your eye), and ensure that the cap is securely replaced after each use to prevent contamination.

If you experience any adverse effects after using eye drops, such as increased redness, irritation, or changes in vision, it is important to seek medical attention promptly. Your eye health is paramount, and any concerns regarding your medications should be addressed with a healthcare professional.

In summary, while refrigeration may seem like a good idea for preserving medications, it is not universally applicable to all eye drops. Always refer to the storage instructions provided with your medication, and when in doubt, consult with a healthcare professional to ensure that you are using your eye drops safely and effectively.

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