Stopping Menstrual Delay Medication: What to Expect After Side Effects? - Obstetrics and Gynecology

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The side effects are too severe, and I want to discontinue the use of the menstrual medication?


I am planning to travel soon and will be participating in underwater activities, so I bought a medication to delay my period (Lemifene tablets) from the pharmacy.
I started taking it five days before my expected period, intending to delay my period for two days, taking one tablet each night before bed.
However, after taking the second tablet, I experienced severe side effects, including nausea that kept me awake all night, significantly affecting my sleep schedule.
I would like to know what the consequences would be if I stop taking the medication after having taken two tablets, considering my period is still expected to arrive in three days.
For example, could it cause my period to come early? Currently, I have not noticed any unusual discharge, only a slight dull pain in my lower abdomen.
Thank you.

Esther, 20~29 year old female. Ask Date: 2022/09/20

Dr. Huang Yuande reply Obstetrics and Gynecology


Menstruation typically occurs about 2 to 3 days after stopping the medication, and that is all.

Reply Date: 2022/09/20

More Info


When it comes to stopping menstrual delay medication, such as the one you mentioned (likely referring to a medication like Norethisterone), it’s important to understand how these medications work and what to expect after discontinuation.
Menstrual delay medications are typically hormonal treatments that can postpone menstruation by altering the natural hormonal cycle. When you take these medications, they essentially prevent the shedding of the uterine lining, which is what occurs during a menstrual period. The side effects you experienced, such as nausea and difficulty sleeping, are not uncommon and can occur due to the hormonal changes induced by the medication.

In your case, since you have already taken two doses of the medication and are considering stopping it, here’s what you can generally expect:
1. Return of Menstrual Cycle: If you stop taking the medication, your body will likely resume its natural hormonal cycle. This means that your period may come as expected, or it could be slightly delayed depending on how your body reacts to the sudden withdrawal of the medication. It’s not uncommon for some individuals to experience a period that arrives earlier than anticipated after stopping the medication, while others may find that their cycle remains unchanged.

2. Potential Side Effects: After discontinuing the medication, you may experience some withdrawal symptoms or side effects as your body readjusts. These can include mild cramping, mood swings, or changes in your menstrual flow. However, since you have only taken the medication for a short period, significant withdrawal symptoms are less likely.

3. Timing of Menstruation: Given that you started the medication five days before your expected period, stopping it after two doses may not significantly alter the timing of your menstruation. It is possible that your period could start on time or be slightly delayed, but it is unlikely to be drastically affected.

4. Monitoring Symptoms: Since you mentioned feeling some mild discomfort in your lower abdomen, it’s important to monitor this. If the discomfort worsens or if you experience any unusual symptoms (such as heavy bleeding or severe pain), it would be advisable to consult a healthcare professional.

5. Consulting a Healthcare Provider: If you have concerns about the side effects you experienced or the impact of stopping the medication, it’s always a good idea to reach out to a healthcare provider. They can provide personalized advice based on your medical history and current health status.

In summary, stopping menstrual delay medication after taking it for a short period is generally safe, and while your menstrual cycle may be affected, significant changes are not expected. Your body will likely readjust, and any discomfort should be monitored. If you have further concerns, especially regarding the side effects you experienced, consulting a healthcare professional would be beneficial. Enjoy your upcoming trip and the water activities you have planned!

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