OCT Results in High Myopia: GCL+ and Retinal Health - Ophthalmology

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I'm sorry, but I need more context or specific information about the "Oct issue" you are referring


Doctor, I have high myopia with one eye at -6.25 and the other at -6.75.
The doctor mentioned that my macula is degenerating and performed OCT on both eyes.
The GCL+ shows a small red area, and the RNFL has a small yellow area.

1.
What does GCL+ represent?
2.
I found online that GCL+ refers to the thickness of the ganglion cell layer near the macula.
Is the presence of the red area related to the degeneration of the macula?
3.
Is it common for high myopia to show yellow and red areas on OCT, but the actual function of the optic nerve and retina remains normal? Thank you, doctor.

Chen, 20~29 year old female. Ask Date: 2022/09/22

Dr. Gao Pilin reply Ophthalmology


Hello, Ms.
Chen:
1.
The ganglion cell layer (GCL) refers to the layer of ganglion cells, and the thickness of the ganglion cell layer plus the inner plexiform layer is denoted as GCL+.
GCL+ is the combination of the ganglion cell layer (GCL) and the thickness of the inner plexiform layer (IPL).

2.
Yellow indicates mild thickening, while red indicates significant thickening.
Regarding whether this is related to macular degeneration, it may be best to consult your attending physician for an explanation, as I cannot determine this without conducting an examination.

Reply Date: 2022/09/22

More Info


Understanding the results of Optical Coherence Tomography (OCT) in the context of high myopia is crucial for assessing retinal health, particularly in relation to the ganglion cell layer (GCL+) and the implications of any abnormalities observed.

1. What is GCL+?
GCL+ refers to the combined thickness of the ganglion cell layer (GCL) and the inner plexiform layer (IPL) of the retina. The GCL is critical as it contains the cell bodies of the ganglion cells, which are responsible for transmitting visual information from the retina to the brain. The IPL is where the synapses between the bipolar cells and ganglion cells occur. A reduction in GCL+ thickness can indicate potential damage or degeneration in the retinal structure, which is particularly concerning in individuals with high myopia, as they are at an increased risk for various retinal pathologies.

2. Interpretation of Red and Yellow Areas in GCL+
The presence of a red area in your GCL+ indicates significant thickening, while yellow typically signifies mild thickening. The relationship between these findings and the degeneration of the macula (yellow spot) is complex. While a red area could suggest localized changes in the retinal structure, it does not necessarily correlate directly with macular degeneration. It is essential to discuss these findings with your ophthalmologist, who can provide insights based on a comprehensive examination and your specific clinical history. High myopia can lead to structural changes in the retina, including elongation of the eyeball, which may contribute to alterations in the GCL+ measurements.

3. Likelihood of Abnormal Findings in High Myopia
Individuals with high myopia often exhibit changes in their OCT results, including variations in GCL+ and RNFL (Retinal Nerve Fiber Layer) thickness. The likelihood of encountering yellow or red areas in OCT scans is indeed higher in this population due to the structural changes associated with elongated axial length and potential retinal thinning or stretching. However, it is important to note that the presence of these abnormalities does not automatically imply dysfunction of the retinal or optic nerve. Many patients with similar OCT findings maintain normal visual function. Regular monitoring and follow-up with your eye care provider are essential to ensure that any changes in your retinal health are detected early and managed appropriately.

In summary, while your OCT results indicate some areas of concern, it is crucial to interpret these findings in the context of your overall eye health and visual function. High myopia increases the risk of retinal issues, but it does not guarantee that significant problems will develop. Regular check-ups, including OCT and visual field assessments, are vital for monitoring your condition. If you experience any changes in your vision or new symptoms, such as flashes or floaters, it is important to seek immediate evaluation from your eye care professional.

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