Dry Eye Syndrome: Blood Test Results and Treatment Insights - Internal Medicine

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Sjögren's Syndrome Index


Thank you, doctor! First question: I was diagnosed with Sjögren's syndrome on August 19 this year, with an index of 280.
Starting from the 20th, I took one quinine daily.
On September 21, I had a second blood test, and the index was 334.
During this period, I also consulted a traditional Chinese medicine practitioner to alleviate my dry mouth, dry eyes, and other symptoms of dryness, which have improved.
However, why has the index increased instead? Does this mean that the quinine is ineffective for me?
Second question: This blood test included a check for Hepatitis B core antibody (Anti-HBc), and the result was Reactive (7.68).
Does this mean I have antibodies (indicating I have had Hepatitis B in the past)?
Third question: Is an IgG level of 1086 within the normal range? What does IgG represent?
Fourth question: The blood test report is as follows: RDW 15.9 [11.5][14.5], RBC 4.90 [4.00][5.20], Platelet 402 [150][400], MCV 73.3 [80.0][100.0], MCHC 31.8 [31.0][37.0], WBC 7.71 [3.50][11.00], Hemoglobin 11.4 [12.0][16.0], Hematocrit 35.9 [36.0][46.0], Erythrocyte Sedimentation Rate (ESR) 2 hours 8 [0][40], ESR 1 hour 4 [0][20], Total Iron Binding Capacity (TIBC) 486.1 [180][497], Serum Iron 26 [43][172], Serum Glutamic Pyruvic Transaminase (SGPT) 16 [5][35].
Do I have anemia? Is it serious? Thank you, doctor, for patiently reading my questions; I am very grateful!

VIVIAN, 40~49 year old female. Ask Date: 2022/09/27

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your questions.
Here are my responses:
First question: I was diagnosed with Sjögren's syndrome on August 19 of this year, with a score of 280.
I started taking one quinine tablet daily from the 20th, and on September 21, my blood was drawn again, showing a score of 334.
During this period, I also consulted a traditional Chinese medicine practitioner to alleviate symptoms of dry mouth and dry eyes, which have improved.
However, why did my score increase instead? Does this mean the quinine is ineffective? --> I'm not sure what you mean by "dryness index." If you are referring to SSA or SSB antibodies, I typically do not check these markers regularly or retest them so soon.
Second question: This blood test included the Hepatitis B core antibody test (Anti-HBc), and the result was Reactive (7.68).
Does this mean I have antibodies (indicating a past Hepatitis B infection)? --> Yes, this indicates that you have been infected with Hepatitis B in the past.
Third question: Is an IgG level of 1086 within the normal range? What does IgG represent? --> The normal range for each laboratory may vary, and the report should include the reference range.
In my hospital, this level is considered within the normal range.
IgG is the most abundant immunoglobulin in the body and can sometimes serve as a reference for immune function activity.
Fourth question: Do I have anemia? Is it severe? --> I would say that your hemoglobin level is somewhat low, but it has not reached the level of anemia.
Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2022/09/27

More Info


Thank you for your detailed questions regarding your health concerns, particularly related to Dry Eye Syndrome and your recent blood test results. I will address each of your inquiries in turn, providing insights based on medical knowledge.


1. Dry Eye Syndrome and Quinine Treatment
You mentioned being diagnosed with an autoimmune dry syndrome in August, with a subsequent increase in your index after starting quinine treatment. It is important to note that while quinine is sometimes used for certain conditions, it is not a standard treatment for dry eye syndrome. The increase in your index could be due to various factors, including the natural progression of your autoimmune condition, other underlying health issues, or even the body’s response to treatment. It’s crucial to discuss this with your healthcare provider, who may consider adjusting your treatment plan or exploring other therapeutic options that specifically target dry eye symptoms.


2. Hepatitis B Core Antibody Test
Your blood test showed a reactive result for the Hepatitis B core antibody (Anti-HBc). This indicates that you have been exposed to the Hepatitis B virus at some point in your life, which could mean you either had a past infection or were vaccinated. It does not necessarily mean you currently have an active infection. Further testing, such as Hepatitis B surface antigen (HBsAg) and Hepatitis B surface antibody (anti-HBs), may be needed to clarify your current status regarding Hepatitis B.


3. IgG Levels
Your IgG level of 1086 is typically considered within the normal range, but this can vary depending on the laboratory's reference values. IgG is a type of antibody that plays a crucial role in the immune response. Elevated IgG levels can indicate chronic infection, autoimmune diseases, or other inflammatory conditions. It would be best to discuss the implications of your specific IgG level with your healthcare provider.


4. Blood Test Results Interpretation
From the blood test results you provided, there are several points to consider:
- Rdw (Red Cell Distribution Width): At 15.9, this is elevated, which may indicate variability in red blood cell sizes, often seen in conditions like anemia.

- RBC (Red Blood Cells): Your count of 4.90 is within the normal range.

- Platelet Count: At 402, this is slightly elevated but generally not concerning unless accompanied by other symptoms.

- MCV (Mean Corpuscular Volume): At 73.3, this is low, suggesting microcytic anemia, which is often due to iron deficiency or thalassemia.

- MCHC (Mean Corpuscular Hemoglobin Concentration): This is within normal limits.

- WBC (White Blood Cells): At 7.71, this is normal.

- Hemoglobin: At 11.4, this is below the normal range for women, indicating anemia.

- Hematocrit: At 35.9, this is also slightly low.

- Iron Studies: Your total iron binding capacity (TIBC) is elevated, while serum iron is low, which can indicate iron deficiency anemia.

Given these results, it appears you may have anemia, likely iron deficiency anemia, which can be serious if left untreated. Symptoms of anemia can include fatigue, weakness, and shortness of breath. It is essential to follow up with your healthcare provider for further evaluation and treatment options, which may include dietary changes or iron supplementation.


Conclusion
In summary, your situation involves multiple factors that require careful monitoring and management. It is crucial to maintain open communication with your healthcare provider, who can help interpret these results in the context of your overall health and guide you in making informed decisions about your treatment. Regular follow-ups and possibly further testing will be necessary to ensure that your conditions are managed effectively. Thank you for your questions, and I wish you the best in your health journey!

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