Chlamydia-Related Urinary Tract Infections and Prostatitis - Urology

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Proteus urinary tract infection


Previously, I had a urinary tract infection caused by Chlamydia for two weeks, which was treated, but it recurred twice.
The doctor diagnosed me with prostatitis and prescribed a one-month treatment specifically for prostatitis, which includes Ciproxin 250 mg, two tablets twice a day, along with a urinalysis.
The urinalysis results showed positive leukocyte esterase and negative results for other tests.
The fungus culture and identification showed no growth for ordinary culture and culture negative for Neisseria gonorrhoeae.
The urine sediment was also negative.
I have been on medication for a week.
Last night, I masturbated before bed, and this morning at 8 AM, I went to the bathroom without any issues.
However, at 10:30 AM, while sitting at the computer, I felt a sensation of residual urine in the urethra.
When I went to the bathroom and squeezed the penis, I expelled a clear, colorless, and odorless fluid resembling prostatic fluid.
What could be the possible issues or diseases related to this? Can the positive leukocyte esterase confirm that there is still an infection?

Mr. Shao, 20~29 year old female. Ask Date: 2022/09/28

Dr. Du Shixi reply Urology


Hello: If there is a possibility of infection due to sexual activity, antibiotics can often treat it.
However, it's important to not only take medication but also to pay attention to lifestyle and practice safe sex.
A positive leukocyte esterase test can indicate the presence of an infection, but it cannot confirm it with 100% certainty.
Wishing you good health.

Reply Date: 2022/09/28

More Info


Chlamydia-related urinary tract infections (UTIs) and prostatitis can be complex and often require careful management. Your situation, involving a previous Chlamydia infection followed by recurrent symptoms and a diagnosis of prostatitis, highlights the need for a thorough understanding of these conditions.

Chlamydia trachomatis is a common sexually transmitted infection (STI) that can lead to urethritis, which is inflammation of the urethra. If left untreated, it can ascend to cause more serious complications, including pelvic inflammatory disease in women and prostatitis in men. Prostatitis, particularly chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), can be challenging to treat and may require a multifaceted approach.

The symptoms you describe, such as a feeling of residual urine and the expulsion of a clear, odorless fluid resembling prostatic fluid, can be indicative of several conditions. The presence of leukocyte esterase in your urine suggests that there may still be some inflammatory process occurring, which could be due to an ongoing infection or irritation of the urinary tract or prostate. However, the absence of bacteria in your cultures is significant; it suggests that a bacterial infection may not be the primary issue.

Here are some potential considerations regarding your symptoms and treatment:
1. Residual Urine Sensation: This sensation can occur due to several factors, including bladder dysfunction, prostatitis, or even anxiety related to previous infections. It is essential to monitor this symptom, especially if it persists or worsens.

2. Prostatic Fluid Expulsion: The clear, odorless fluid you described could be prostatic fluid. In some cases, men with prostatitis may experience the expulsion of prostatic secretions, especially after sexual activity or ejaculation. This is not uncommon and does not necessarily indicate an ongoing infection.

3. Chronic Prostatitis: If your symptoms are consistent with chronic prostatitis, treatment may require a longer duration of antibiotics, typically 4 to 6 weeks or more, depending on the severity and response to initial therapy. Additionally, non-antibiotic treatments such as alpha-blockers, anti-inflammatory medications, and pelvic floor physical therapy may be beneficial.

4. Follow-Up Testing: Given that you have had recurrent symptoms, it may be prudent to follow up with your healthcare provider for additional testing. This could include a repeat urine culture, evaluation for other STIs, or imaging studies if indicated.

5. Psychosomatic Factors: Sometimes, the anxiety surrounding recurrent infections can exacerbate symptoms. Consider discussing these feelings with your healthcare provider, as they may recommend counseling or stress management techniques.

6. Prevention Strategies: To reduce the risk of future UTIs and prostatitis, consider the following:
- Maintain good hydration to promote regular urination.

- Practice safe sex to reduce the risk of STIs.

- Avoid irritants such as caffeine, alcohol, and spicy foods, which can exacerbate urinary symptoms.

- Ensure proper hygiene before and after sexual activity.

In conclusion, while the presence of leukocyte esterase suggests some level of inflammation, it does not definitively confirm an active infection. It is crucial to maintain open communication with your healthcare provider, who can guide you through the next steps in your treatment and management plan. If symptoms persist or worsen, further evaluation may be necessary to rule out other underlying conditions.

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