HPV Vaccine Timing: Concerns After Corticosteroid Injection - Obstetrics and Gynecology

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HPV vaccine and other vaccine-related issues?


Hello Doctor: I am a 36-year-old woman.
My scheduled date for the third dose of the HPV nine-valent vaccine is October 1st.
However, during a visit to the dermatologist on September 27th, I received an injection for acne, which I found out contains a substance commonly known as a steroid.
How long should I wait after receiving this acne injection before getting the HPV vaccine? Can I still receive it on October 1st? Additionally, with the current vaccine shortage, will delaying the vaccination by a few months cause any issues? If I have to wait until the end of this year or January next year to get the vaccine, will it render my previous two doses ineffective? Thank you.

VIVI, 30~39 year old female. Ask Date: 2022/09/28

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have any impact, so you can proceed with the original schedule for the vaccination.
Wishing you good health!

Reply Date: 2022/09/28

More Info


When considering the timing of your HPV vaccination after receiving a corticosteroid injection, it's essential to understand a few key points about both the vaccine and the corticosteroid treatment.

Firstly, corticosteroids can temporarily suppress the immune system, which might affect how your body responds to vaccines. However, the impact of a single corticosteroid injection on the effectiveness of the HPV vaccine is generally minimal. The HPV vaccine is designed to elicit a robust immune response, and while corticosteroids can dampen this response, it is unlikely to negate the benefits of the vaccine entirely.
In your case, since you received the corticosteroid injection on September 27 and are scheduled for your third dose of the HPV vaccine on October 1, it is advisable to consult with your healthcare provider for personalized advice. Many healthcare professionals suggest waiting at least a week after receiving a corticosteroid injection before getting vaccinated. This allows your immune system to recover somewhat from the potential suppressive effects of the steroid. Therefore, postponing your HPV vaccination to a later date, such as a week or two after the injection, could be a prudent choice.

Regarding the concern about vaccine shortages and the potential impact on the efficacy of your previous doses, it's important to note that the HPV vaccine series is designed to be flexible. The Centers for Disease Control and Prevention (CDC) states that if there is a delay in receiving the third dose, it is still beneficial to complete the series, even if it takes longer than the recommended schedule. The immunity developed from the first two doses will not be rendered ineffective due to a delay in the third dose. However, it is ideal to complete the series as soon as possible to ensure optimal protection against HPV-related diseases.

If you find that the vaccine is unavailable until the end of the year or early next year, do not worry excessively about the efficacy of the first two doses. The protection conferred by the initial doses will still be present, and completing the series later will still provide you with the necessary immunity against the HPV types covered by the vaccine.

In summary, while it is generally safe to receive the HPV vaccine shortly after a corticosteroid injection, waiting a week or so may be beneficial. If you experience any side effects or have concerns about the timing, it is always best to consult with your healthcare provider. They can provide guidance tailored to your specific health situation. Additionally, if there are delays in receiving the vaccine, rest assured that your previous doses will still offer protection, and completing the series at a later date will still be effective.

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