Post-Treatment Side Effects of Tumor Therapy: A Comprehensive Overview

Late effects related to tumor treatment?

Is it possible to experience the following side effects from using lactation induction therapy for breast cancer? Bilateral myopia, bilateral dry eye syndrome, and bilateral vitreous degeneration.
Prior to treatment, myopia was between 150 to 200 degrees without the aforementioned degenerative issues, but after treatment, presbyopia and the symptoms mentioned began to appear; there are also problems with the oral cavity and tympanic membrane.
Candidiasis of the oral cavity and glossodynia.
It is noted that a significant decrease in saliva secretion occurred only after treatment.
Bilateral tinnitus and chronic otitis externa are also reported.
It was noted that prior to treatment, there was moisture in the ears, but after treatment, they became completely dry, leading to itching.
Is there literature available to provide to the insurance company for underwriting? Relevant diagnostic information has already been provided.
Thank you for your response.

Monica, 40~49 year old female. Ask Date: 2022/10/06

Dr. Hu Ziren reply Oncology

Taking Fluoxetine can indeed cause blurred vision and cataracts.
It is recommended to consult a pharmacist or read the medication insert thoroughly.
For more information, you can refer to the following link: https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005FEM01.pdf or search for the Fluoxetine medication insert on Google.

Reply Date: 2022/10/06

More Info

Post-treatment side effects of tumor therapy can vary widely depending on the type of treatment received, the specific medications used, and the individual patient's response. In the case of using Tamoxifen (復乳納) for breast cancer, it is important to understand both the common and less common side effects associated with this medication and other cancer treatments.

Tamoxifen is a selective estrogen receptor modulator (SERM) commonly used in hormone receptor-positive breast cancer. While it is effective in reducing the risk of cancer recurrence, it can also lead to a range of side effects. Some of the more common side effects include hot flashes, vaginal dryness, mood swings, and fatigue. However, the side effects you are experiencing, such as bilateral myopia, dry eye syndrome, vitreous degeneration, oral thrush, and tinnitus, are less commonly associated with Tamoxifen and may warrant further investigation.

1. Visual Changes: The development of bilateral myopia and presbyopia (老花眼) after starting Tamoxifen is unusual. While some cancer treatments can affect vision, it is essential to consult an ophthalmologist to determine if these changes are directly related to the medication or if they are due to other factors, such as age or underlying conditions.

2. Dry Eye Syndrome: This condition can be exacerbated by hormonal changes, which Tamoxifen may induce. The decrease in tear production can lead to discomfort, redness, and visual disturbances. Artificial tears or other treatments may be recommended by an eye care professional.

3. Vitreous Degeneration: This condition involves changes in the gel-like substance in the eye and can lead to floaters or visual disturbances. While it is not a common side effect of Tamoxifen, it can occur with age or other ocular conditions. An eye specialist can provide a thorough evaluation.

4. Oral Thrush and Stomatitis: A decrease in saliva production (xerostomia) can lead to oral thrush (念珠菌性口炎) and discomfort in the mouth. This side effect can be related to various factors, including medication effects, and should be addressed with a healthcare provider. Maintaining good oral hygiene and possibly using saliva substitutes may help alleviate symptoms.

5. Tinnitus and Ear Issues: The development of bilateral tinnitus and chronic external otitis (慢性外耳炎) could be related to changes in the body's hormonal balance or other factors. If the ears were previously moist and are now dry, this could lead to irritation and discomfort. An ENT specialist can evaluate these symptoms and recommend appropriate treatments.

6. Salivary Gland Dysfunction: The noticeable decrease in saliva production following treatment can significantly impact oral health and quality of life. This condition can lead to difficulties in swallowing, speaking, and increased risk of dental issues. Management strategies may include hydration, saliva substitutes, and regular dental check-ups.

In summary, while some of the symptoms you are experiencing may not be directly linked to Tamoxifen, they could be influenced by the overall changes in your body due to cancer treatment. It is crucial to discuss these symptoms with your healthcare provider, who may refer you to specialists such as an ophthalmologist, ENT, or dentist for further evaluation and management. Documenting these side effects and any changes in your health can be beneficial for insurance claims or further medical assessments. Always ensure that any new symptoms are reported to your healthcare team promptly to receive appropriate care.

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