the Risks of Adenomas and Colon Cancer After Polypectomy - Gastroenterology and Hepatology

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Adenoma found during colonoscopy?


Hello, Dr.
Tsai: I would like to ask you about a recent colonoscopy I had, which revealed a benign adenoma smaller than 1 centimeter.
It has been removed, and I am scheduled for follow-up examinations every two years to check for any dysplasia.
I am concerned about the risk of progression to colorectal cancer.
If I continue to have regular follow-ups every two years and any small adenomas found are completely removed, is it likely that they will not progress to colorectal cancer? Additionally, can an adenoma smaller than 0.7 centimeters also potentially be malignant? Thank you for addressing these two questions.

Mr. Han, 40~49 year old female. Ask Date: 2022/10/23

Dr. Cai Jinji reply Gastroenterology and Hepatology


Hello Mr.
Han: If there are small adenomas, it is advisable to address them, as this will certainly reduce the risk of progression to colorectal cancer; however, it is not absolute, as there are many factors involved.
Adenomas are generally benign, but if left untreated, they may become malignant.
Director Cai Jin-ji, Department of Hepatobiliary and Gastroenterology, Nantou Hospital.

Reply Date: 2022/10/23

More Info


After undergoing a polypectomy, particularly for adenomas, it is understandable to have concerns regarding the potential risks of developing colorectal cancer. Adenomas are benign tumors that can, in some cases, progress to colorectal cancer if left untreated. The risk of malignant transformation is influenced by several factors, including the size, histological type, and degree of dysplasia of the adenoma.

1. Risk of Progression to Colorectal Cancer: The risk of an adenoma progressing to colorectal cancer increases with its size. Adenomas that are less than 1 cm in size, particularly those that are tubular adenomas, have a relatively low risk of malignant transformation. However, tubulovillous and villous adenomas, even when small, carry a higher risk. The general consensus is that adenomas smaller than 0.5 cm have a very low risk of cancer, while those between 0.5 cm and 1 cm may have a moderate risk, especially if they exhibit dysplastic changes.
2. Regular Surveillance: Regular surveillance through colonoscopy is crucial for individuals who have had adenomas removed. The recommendation is typically to have follow-up colonoscopies every 3 to 5 years, depending on the number and type of adenomas found during the initial procedure. If you are having adenomas removed consistently during your follow-up exams, this significantly reduces the risk of developing colorectal cancer. The key is to ensure that any new adenomas are detected and removed promptly.

3. Small Adenomas and Malignancy: Regarding your concern about small adenomas (less than 0.7 cm), while the majority of these are benign, there is still a possibility, albeit low, that they could harbor malignant changes. The risk is particularly higher in adenomas that are tubulovillous or villous in nature. Therefore, even small adenomas should be monitored closely, and any changes in their appearance or characteristics should be evaluated by your healthcare provider.

4. Importance of Follow-Up: It is essential to adhere to the follow-up schedule recommended by your physician. If you consistently have adenomas that are removed and monitored, your risk of developing colorectal cancer can be significantly mitigated. However, it is also important to maintain a healthy lifestyle, including a balanced diet rich in fiber, regular exercise, and avoiding smoking and excessive alcohol consumption, as these factors can also influence colorectal cancer risk.

In summary, while the presence of adenomas does increase the risk of colorectal cancer, regular surveillance and prompt removal of any new adenomas can greatly reduce this risk. It is advisable to maintain open communication with your healthcare provider regarding your follow-up care and any concerns you may have. Regular screenings and a proactive approach to your health can help ensure that any potential issues are addressed before they develop into more serious conditions.

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