Chronic Fatigue: When to See a Doctor for Liver Health Concerns - Gastroenterology and Hepatology

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Feeling particularly fatigued every day?


I feel particularly fatigued every day, and it feels like I haven't slept at all when I wake up.
During my health check-up, my SGOT result was 12, with a reference range of 15-37 U/L.
Should I see a doctor for this?

Yang Xiaofen, 30~39 year old female. Ask Date: 2022/11/03

Dr. Chen Shidian reply Gastroenterology and Hepatology


GOT12 does not experience fatigue.
If symptoms persist or worsen, a consultation with a metabolic specialist is recommended to diagnose the underlying cause.

Reply Date: 2022/11/03

More Info


Chronic fatigue can be a debilitating condition that significantly impacts your quality of life. It is essential to understand that fatigue can stem from various causes, including physical, psychological, and lifestyle factors. Given your symptoms of persistent tiredness and the specific lab results you provided, it is prudent to consider a comprehensive approach to your health.

Firstly, the SGOT (serum glutamic oxaloacetic transaminase), also known as AST (aspartate aminotransferase), is an enzyme found in the liver and other tissues. Your result of 12 U/L, which is below the reference range of 15-37 U/L, indicates that your liver function in this regard is normal. However, it is crucial to remember that liver health cannot be assessed solely based on one enzyme level. Other liver function tests, such as SGPT (ALT), alkaline phosphatase, bilirubin levels, and additional markers, should be evaluated to get a complete picture of liver health.

Chronic fatigue can be associated with liver conditions, particularly if there are underlying issues such as fatty liver disease, hepatitis, or even liver cirrhosis. However, since your SGOT is within the normal range, it may not be the primary cause of your fatigue. It is essential to consider other factors that could contribute to your symptoms.
1. Lifestyle Factors: Evaluate your daily habits. Are you getting enough sleep? Is your diet balanced? Lack of physical activity, poor nutrition, and inadequate sleep can all lead to feelings of fatigue. Engaging in regular exercise, maintaining a healthy diet, and ensuring you get quality sleep can significantly improve your energy levels.

2. Psychological Factors: Chronic fatigue can also be linked to mental health issues such as depression or anxiety. If you find that your fatigue is accompanied by feelings of sadness, hopelessness, or anxiety, it may be beneficial to consult a mental health professional.

3. Other Medical Conditions: There are numerous medical conditions that can cause chronic fatigue, including anemia, thyroid disorders, sleep apnea, and chronic infections. If your fatigue persists despite lifestyle changes, it may be necessary to undergo further testing to rule out these conditions.

4. When to See a Doctor: Given your ongoing fatigue and the fact that it is affecting your daily life, it is advisable to consult a healthcare provider. They can conduct a thorough evaluation, including a detailed medical history, physical examination, and possibly additional blood tests to assess other liver enzymes and overall health. If necessary, they may refer you to a specialist, such as a hepatologist or an endocrinologist, depending on the findings.

In summary, while your SGOT level appears normal, chronic fatigue warrants further investigation. It is essential to consider a holistic approach that includes lifestyle modifications, psychological evaluation, and possibly further medical testing. Seeking medical advice will help you identify the underlying cause of your fatigue and guide you toward appropriate treatment options. Remember, addressing chronic fatigue often requires a multi-faceted approach, and working closely with healthcare professionals can lead to significant improvements in your quality of life.

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