Am I Suffering from Thalassemia? Blood Test Results - Family Medicine

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Am I suffering from thalassemia?


Hello, Dr.
Huang...
I have two questions to ask...
1.
Previously, my MCV was always above 85, and my MCH was around 27 (the standard value is 28-36).
My MCHC was about 30.
Recently, during a health check, I found that my MCH is 24.9; MCV is 77.6; MCHC is 32.2; Hb is 11.0; Ht is 34.2; WBC is 5.04; RBC is 4.41; and platelets are 321.
Could I have thalassemia? Do the MCV values in individuals with thalassemia change, or are they consistently low? (I am particularly concerned because I am getting married next year and it relates to having children...) 2.
In my urine test, the specific gravity is 1.026; pH is 5.0; occult blood is 1+; and everything else is normal.
I have no discomfort, but the presence of occult blood is concerning.
Could this indicate an infection, or should I quickly see a nephrologist?

Irene, 20~29 year old female. Ask Date: 2003/10/21

Dr. Huang Mingde reply Family Medicine


1.
The change in your MCV value is more suggestive of thalassemia, but it is still recommended to visit the outpatient clinic for further differential diagnosis.
2.
The positive OB (occult blood) may be caused by infection, inflammation, stones, or tumors, and it is advisable to have a follow-up with a nephrologist approximately every month.

Reply Date: 2003/10/21

More Info


When interpreting blood test results, particularly in the context of potential thalassemia or other hematological conditions, it is essential to consider various parameters and their implications. Based on the values you provided, let's break down your concerns regarding thalassemia and the urinary findings.


1. Thalassemia Assessment
Thalassemia, particularly the beta-thalassemia trait or minor, is characterized by microcytic anemia, which is often indicated by low mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). In your case, the recent blood test shows:
- MCV: 77.6 (normal range: 80-100 fL)
- MCH: 24.9 (normal range: 28-36 pg)
- Hemoglobin (Hb): 11.0 g/dL (normal range: 12.0-16.0 g/dL for females)
- Hematocrit (Ht): 34.2% (normal range: 36-46% for females)
These results indicate microcytic anemia, which could be consistent with thalassemia or iron deficiency anemia. Thalassemia patients typically have consistently low MCV and MCH values, but they can fluctuate based on various factors, including iron status and other underlying conditions.
Given your previous MCV values were above 85, the recent drop could suggest a change in your health status, possibly due to nutritional deficiencies, chronic disease, or even the onset of thalassemia. It is crucial to conduct further tests, such as hemoglobin electrophoresis, to determine the specific type of thalassemia or to rule out other causes of microcytic anemia.

2. Urinalysis Findings
Regarding your urinalysis results, the specific gravity (SP.GR) of 1.026 is within normal limits, indicating adequate hydration. The pH of 5.0 is slightly acidic, which can be normal depending on diet and hydration status. However, the presence of occult blood (1+) is noteworthy.
Occult blood in urine can arise from various causes, including:
- Infection: Urinary tract infections (UTIs) can cause hematuria (blood in urine).

- Kidney Stones: These can irritate the urinary tract and lead to bleeding.

- Trauma: Any injury to the urinary tract can result in blood.

- Glomerular Disease: Conditions affecting the kidneys can also lead to blood in the urine.

Since you mentioned that you have no discomfort or other symptoms, it may not be an urgent issue, but it is advisable to follow up with a healthcare provider. They may recommend further evaluation, including a urinalysis culture, imaging studies, or a referral to a nephrologist if necessary.


Conclusion
In summary, your blood test results indicate the possibility of thalassemia or another form of microcytic anemia, and further testing is warranted to clarify the diagnosis. The presence of occult blood in your urine should also be investigated to rule out any underlying conditions. Given your upcoming marriage and plans for children, addressing these health concerns proactively is essential. It is advisable to consult with a hematologist for the blood results and a urologist or nephrologist for the urinary findings to ensure comprehensive care.

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