the Impact of Propranolol on Asthma and COPD Symptoms - Pulmonology

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Drug side effects in chronic obstructive pulmonary disease (COPD)?


I consulted a cardiologist two years ago who was unaware of my asthma condition.
They strongly encouraged me to take the sedative Ambien and the antiarrhythmic drug Propranolol.
After a month of taking these medications, my asthma symptoms worsened to the point where it felt like I had obstructive lung disease.
I struggled to breathe and often felt like I was running out of air.
When I accidentally combined antihistamines with Ambien, my palpitations intensified, prompting me to stop taking them.
After discontinuing the medications, I experienced significant shortness of breath while talking, exercising, or climbing stairs.
My palpitations became more frequent.
Since two years ago, I have noticed that my blood oxygen levels drop to 70 after meals and even during sleep.
This year, I borrowed a nebulizer from a friend, which has helped stabilize my blood oxygen levels, preventing them from dropping during the night.
However, my heart has become increasingly weak, making it difficult to leave the house.
Yesterday, I intended to have my doctor measure my ECG and thought I would exercise a bit first.
However, halfway up the stairs, I found myself unable to stand and had to collapse there, gasping for breath.
I haven't dared to exercise for two years because any physical activity leaves me feeling like I want to jump off a building.

Could the medications Ambien and Propranolol have caused bronchoconstriction, leading to my asthma worsening into obstructive lung disease? Additionally, has this contributed to my declining cardiopulmonary function? What should I do next, as I am unable to leave the house?

nv po, 40~49 year old female. Ask Date: 2022/11/17

Dr. Zhou Ziguang reply Pulmonology


Hello: Please first visit the pulmonary medicine department for treatment, adjust your medication, and provide your past medical history (including medications).

Reply Date: 2022/11/17

More Info


Propranolol is a non-selective beta-blocker commonly used to manage conditions such as hypertension, anxiety, and certain types of heart rhythm disorders. However, its use in patients with asthma or chronic obstructive pulmonary disease (COPD) requires careful consideration due to its potential effects on the respiratory system.

In patients with asthma, beta-blockers like propranolol can lead to bronchoconstriction, which is a tightening of the muscles around the airways. This can exacerbate asthma symptoms and lead to increased difficulty in breathing, as you have experienced. The mechanism behind this is that propranolol blocks beta-2 adrenergic receptors, which are responsible for relaxing bronchial smooth muscle. In individuals with asthma, this can result in a significant worsening of respiratory symptoms, including wheezing, shortness of breath, and even feelings of suffocation.

Your experience of feeling like you were unable to breathe and the sensation of your asthma worsening to the point of feeling like you had lung obstruction could indeed be attributed to the use of propranolol, especially if it was prescribed without a full understanding of your asthma history. Additionally, combining propranolol with other medications, such as antihistamines or sedatives, can further complicate your respiratory status, leading to increased side effects like heart palpitations and shortness of breath.

It is also important to note that the symptoms you described, such as frequent heart palpitations and significant drops in oxygen saturation, are concerning and warrant immediate medical attention. These symptoms may indicate that your heart is under stress, possibly due to the combination of medications and your underlying respiratory condition.

In terms of managing your situation, it is crucial to communicate openly with your healthcare provider about all the medications you are taking and any side effects you are experiencing. Your doctor may need to adjust your medications, potentially switching you to a different class of drugs that does not have the same respiratory side effects as propranolol. For instance, if you require a beta-blocker for heart-related issues, a cardioselective beta-blocker (which primarily affects the heart and has less impact on the lungs) might be a safer option.

Furthermore, it may be beneficial to involve a pulmonologist in your care. A specialist in lung conditions can provide a more comprehensive evaluation of your asthma and COPD, and help develop a tailored treatment plan that addresses both your respiratory and cardiac needs. This could include optimizing your inhaler regimen, considering the use of corticosteroids for inflammation, and ensuring that your asthma is well-controlled to prevent exacerbations.

In summary, propranolol can have significant impacts on asthma and COPD symptoms, particularly in individuals with a history of respiratory issues. It is essential to work closely with your healthcare team to monitor your symptoms, adjust medications as necessary, and ensure that both your heart and lung health are being appropriately managed. If you experience severe symptoms or a significant decline in your ability to breathe, seek medical attention immediately. Your health and safety should always be the top priority.

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