Do You Need Kidney Function Tests Before Fluorescein Angiography? - Ophthalmology

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Preparation for Fluorescent Contrast Agents


I would like to ask if a blood test for kidney function is necessary before undergoing fundus angiography during an outpatient appointment.

Ye Mo Xia, 30~39 year old female. Ask Date: 2022/11/20

Dr. Gao Pilin reply Ophthalmology


Hello: This step is usually not required, but if there are severe abnormalities in liver or kidney function, or if there are any allergic conditions, please inform the physician first.

Reply Date: 2022/11/20

More Info


Before undergoing fluorescein angiography, a common procedure in ophthalmology to visualize the blood vessels in the retina, it is generally not a standard requirement to perform kidney function tests. However, there are specific circumstances where assessing kidney function may be prudent, particularly if the patient has pre-existing renal issues or other risk factors.

Fluorescein angiography involves the intravenous injection of fluorescein dye, which can be excreted by the kidneys. In patients with compromised kidney function, the use of this dye could potentially lead to adverse effects, including nephrotoxicity or allergic reactions. Therefore, if a patient has a history of significant renal impairment, such as chronic kidney disease (CKD), it is advisable to inform the ophthalmologist prior to the procedure. The physician may then decide to conduct kidney function tests to evaluate the patient's renal status before proceeding with the angiography.

In general, the standard kidney function tests include serum creatinine levels and the estimated glomerular filtration rate (eGFR). These tests help determine how well the kidneys are filtering waste products from the blood. For patients with an eGFR below 30 mL/min, the risk of complications from the use of fluorescein dye increases, and alternative imaging methods may be considered.

Moreover, if the patient has a history of allergies, particularly to iodinated contrast materials or fluorescein, this should also be communicated to the healthcare provider. Allergic reactions can range from mild to severe, and premedication may be necessary in some cases.

In summary, while routine kidney function tests are not typically required before fluorescein angiography, they are recommended for patients with known renal impairment or other risk factors. It is essential for patients to have open communication with their healthcare providers about their medical history, including any kidney issues or allergies, to ensure the safest and most effective care. If there are any concerns regarding kidney function or the use of fluorescein dye, patients should discuss these with their ophthalmologist, who can provide personalized recommendations based on their specific health status.

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