Am I Unsuitable for SSRI Medications? Exploring Alternatives for Panic Disorder - Psychiatry

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Am I really not suitable for taking SSRIs?


The doctor would like to ask you: I have panic disorder and recently I was taking ERA long-acting sleeping pills and antiarrhythmic medication before bed.
However, I informed my doctor that I felt unusually fatigued and heavy in the body after noon, so I was switched to taking half a tablet of Clonazepam, half a tablet of Zoloft, and half a tablet of antiarrhythmic medication before bed.
However, I wake up the next day with palpitations, trembling, a constant feeling of impending panic, no appetite but feeling very hungry, and diarrhea.
Previously, when I was taking benzodiazepines, I did not experience these symptoms; they only started after switching to Clonazepam.
My attending physician told me that only SSRIs can address the root cause.
I would like to ask the doctor if I am truly unsuitable for serotonergic medications, and what other medications could help me address the underlying issue?

Xiao An, 20~29 year old female. Ask Date: 2022/12/06

Dr. Liang Sunyuan reply Psychiatry


Hello Xiao An: If you experience discomfort after changing your medication, it is advisable to discuss it with your physician during your follow-up appointment.
Your feelings and discomfort are clearly expressed in your message, and I believe the doctor will understand and make appropriate adjustments for you.
Wishing you a speedy recovery.

Reply Date: 2022/12/06

More Info


When considering the suitability of SSRIs (Selective Serotonin Reuptake Inhibitors) for treating panic disorder, it’s essential to understand both the potential benefits and the side effects associated with these medications. SSRIs are commonly prescribed for anxiety disorders, including panic disorder, due to their effectiveness in increasing serotonin levels in the brain, which can help improve mood and reduce anxiety symptoms.

From your description, it seems that you have been experiencing significant side effects after switching to citalopram (Kexin) and other medications. Symptoms such as palpitations, tremors, loss of appetite, and gastrointestinal issues like diarrhea can be distressing and may indicate that your body is reacting negatively to the current medication regimen. It's important to communicate these symptoms to your healthcare provider, as they can help determine whether these side effects are temporary or if they warrant a change in your treatment plan.

Your doctor’s assertion that SSRIs are necessary for treating the root cause of your panic disorder is based on the understanding that these medications can help stabilize mood and reduce anxiety over time. However, it is also crucial to recognize that not every patient responds to SSRIs in the same way. Some individuals may experience intolerable side effects or may not find relief from their symptoms while on these medications. In such cases, it’s essential to explore alternative treatments.

There are several alternatives to SSRIs that may be considered for treating panic disorder:
1. Benzodiazepines: While you mentioned having previously taken benzodiazepines (BZD) without adverse effects, these medications are typically used for short-term relief of anxiety symptoms due to their sedative effects. They can be effective for acute anxiety but are not recommended for long-term use due to the risk of dependence.

2. Other Antidepressants: Medications such as SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) like venlafaxine (Effexor) or duloxetine (Cymbalta) may be effective alternatives. They work by increasing both serotonin and norepinephrine levels in the brain and may be beneficial for anxiety disorders.

3. Buspirone: This is an anxiolytic that is not chemically related to benzodiazepines and may help with anxiety without the sedative effects. It can take several weeks to see the full effects, but it may be a suitable option for some patients.

4. Cognitive Behavioral Therapy (CBT): This is a highly effective non-pharmacological treatment for panic disorder. CBT focuses on changing negative thought patterns and behaviors associated with anxiety and panic attacks. Many patients find significant relief from their symptoms through therapy alone or in combination with medication.

5. Lifestyle Modifications: Incorporating regular exercise, mindfulness practices, and relaxation techniques can also help manage anxiety symptoms. These approaches can complement medication and provide additional coping strategies.

6. Natural Supplements: Some individuals explore herbal supplements such as St. John’s Wort or omega-3 fatty acids, which may have mood-stabilizing effects. However, it’s crucial to consult with a healthcare provider before starting any supplements, especially if you are on other medications.

In conclusion, while SSRIs are a common treatment for panic disorder, they are not the only option, and your experience with side effects is valid and important. It’s essential to have an open dialogue with your healthcare provider about your symptoms and concerns. Together, you can explore alternative treatments that may be more suitable for your individual needs. Remember, finding the right treatment can take time, and it’s okay to seek adjustments to your medication or explore different therapeutic approaches. Your mental health is paramount, and there are various paths to achieving stability and relief from panic disorder.

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