Is Blood Testing for Hormones Accurate After Taking Birth Control Pills? - Obstetrics and Gynecology

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Is it still accurate to test hormone levels through blood tests after taking pre-exposure prophylaxis (PrEP)?


Hello! I would like to have blood tests for follicle-stimulating hormone (FSH), prolactin, and other related ovarian checks.
However, I have been taking a one-month course of oral contraceptives to regulate my menstrual cycle, and after finishing the course, my period did not come (it was already light to begin with) and instead, I have brown discharge.
At this point, would the results of the blood tests still be reliable? Would you recommend that I pause the oral contraceptives for two weeks or wait a month before having the blood drawn? Additionally, is the change in my menstrual flow after taking the oral contraceptives a cause for concern? Thank you.

Niming, 30~39 year old female. Ask Date: 2022/12/07

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, after stopping the medication, you should test again.
Normally, your period should come 3-4 days after finishing the birth control pills.
If it has been over a week and you still haven't gotten your period, it is advisable to see a gynecologist.
Wishing you good health.

Reply Date: 2022/12/07

More Info


When considering blood testing for hormones after taking birth control pills, it's important to understand how hormonal contraceptives can influence the results of such tests. Birth control pills contain synthetic hormones that can alter the natural hormonal balance in your body, which may affect the levels of hormones like Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Prolactin in your blood.

1. Timing of Blood Tests: The accuracy of hormone level tests can be significantly influenced by the timing of the test in relation to your menstrual cycle and the use of hormonal contraceptives. Generally, it is recommended to perform hormone testing during specific phases of your cycle for the most accurate results. For instance, FSH and LH are typically measured on cycle days 2-4, while Prolactin can be tested at any time, but it’s often best to do so in the morning after fasting. If you have recently stopped taking birth control pills, it may take some time for your hormone levels to return to their baseline, making immediate testing less reliable.

2. Impact of Birth Control Pills: Since you have been on birth control pills for a month, your body is still adjusting to the hormonal changes. The presence of brown discharge instead of a regular menstrual period could indicate that your body is responding to the hormonal changes induced by the pills. This is not uncommon, especially if you have a history of irregular periods or light menstrual flow. The brown discharge typically signifies older blood that is taking longer to exit the uterus, which can be a normal response to hormonal fluctuations.

3. Recommendations: It would be advisable to wait at least one full cycle after stopping the birth control pills before conducting hormone tests. This allows your body to reset and your hormone levels to stabilize, providing a clearer picture of your ovarian function and overall hormonal health. If you are experiencing persistent irregularities or concerning symptoms, it may be beneficial to consult with your healthcare provider sooner.

4. Potential Issues: If you continue to experience irregular bleeding or unusual discharge after stopping the pills, it could indicate an underlying issue that may need further investigation. Conditions such as Polycystic Ovary Syndrome (PCOS), thyroid disorders, or other hormonal imbalances could be at play. It’s essential to communicate any ongoing symptoms to your healthcare provider, who may recommend additional testing or monitoring.

5. Conclusion: In summary, while blood tests for hormones can provide valuable insights into your reproductive health, the timing and context of these tests are crucial, especially after using hormonal contraceptives. It is generally best to wait until your body has had time to adjust after stopping the pills before undergoing hormone testing. If you have concerns about your menstrual cycle or hormonal health, do not hesitate to reach out to your healthcare provider for personalized advice and support. They can guide you on the best course of action based on your specific circumstances and health history.

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