Managing Heavy Menstrual Bleeding: Medrone and Estrade for Treatment

Medrone tablets and Estrade?

From September to October, there was heavy menstrual bleeding that lasted an entire month with significant blood loss.
I eventually took hemostatic medication and received a blood transfusion.
In November, I did not have a period, but in December, my period lasted for 13 days without stopping.
During a follow-up appointment, the doctor prescribed Medrone (methylprednisolone) and Estrade (estradiol) for hemostasis and regulation.
The next day, it seemed like the bleeding was almost gone.
Should I continue taking the medication? The doctor mentioned starting with these medications to see if there is a hormonal imbalance, and currently, no cause has been identified for the excessive bleeding and prolonged duration.
An ultrasound appeared normal, showing only a benign cyst (suspected polycystic ovary syndrome), and the CA-125 level was normal.
Should I go ahead with a hysteroscopy (without anesthesia)? This would allow for immediate assessment of any potential issues within the uterus, such as polyps.
I am not considering using premedication to regulate my cycle at this time.

Niming, 30~39 year old female. Ask Date: 2022/12/13

Dr. Zhang Kunmin reply Obstetrics and Gynecology

Hello, the current recommendation is not to discontinue medication; please consult with your treating physician first.
There are many factors that can affect the menstrual cycle or cause intermenstrual bleeding, such as age, environment, lifestyle, stress, emotional instability, weight changes, medications, emergency contraception, diet, polycystic ovary syndrome, uterine or cervical lesions, infections, ovulation, pregnancy, miscarriage, and breastfeeding, among others.
If your symptoms persist or worsen, it is advisable to seek evaluation from your physician, who can arrange for relevant examinations based on your clinical condition.
Thank you! Wishing you peace and health, Dr.
Zhang.

Reply Date: 2022/12/13

More Info

Managing heavy menstrual bleeding can be a complex issue, especially when it involves prolonged periods and significant blood loss. In your case, it seems that you have experienced heavy menstrual bleeding for an extended period, leading to the use of hemostatic medications and even blood transfusions. The medications prescribed by your doctor, Medrone (methylprednisolone) and Estrade (estradiol), are commonly used to manage such conditions.

Medrone (Methylprednisolone) is a corticosteroid that can help reduce inflammation and may also play a role in managing certain bleeding disorders by modulating the immune response. It is not typically the first-line treatment for heavy menstrual bleeding but can be used in specific cases where inflammation or an autoimmune component is suspected.

Estrade (Estradiol) is a form of estrogen that can help regulate the menstrual cycle and is often used in cases of hormonal imbalance. It can assist in stabilizing the endometrial lining, potentially reducing excessive bleeding. The combination of these two medications aims to address both the immediate symptoms of heavy bleeding and the underlying hormonal imbalance.

Given that your bleeding has decreased significantly after starting the medication, it may be beneficial to continue with the prescribed treatment as directed by your healthcare provider. However, it is essential to monitor your symptoms closely. If the bleeding resumes or if you experience any adverse effects from the medications, you should contact your doctor immediately.

Regarding the need for a hysteroscopy (a procedure to look inside the uterus), it can be a valuable diagnostic tool, especially if there is a concern about structural abnormalities such as polyps or fibroids that could be contributing to your heavy bleeding. A hysteroscopy can be performed without general anesthesia in many cases, and it allows for direct visualization of the uterine cavity. If your doctor suspects that there may be an underlying issue that has not been identified through ultrasound, this procedure could provide more definitive answers.

In your situation, since the ultrasound showed a benign cyst and normal CA-125 levels, it may not be immediately necessary to undergo a hysteroscopy unless your symptoms persist or worsen. However, if your doctor recommends it as part of a thorough evaluation, it would be wise to consider it, especially if it could lead to a more effective treatment plan.

In summary, continue taking the medications as prescribed while monitoring your symptoms. If the bleeding returns or if you have concerns about the medications, consult your healthcare provider. A hysteroscopy could be a useful next step if your symptoms do not improve or if there are indications of potential uterine abnormalities. Always ensure that you have open communication with your healthcare team to address any concerns and to tailor the treatment plan to your specific needs.

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