Choosing the Right OCD Treatment for Patients with Cardiovascular History - Psychiatry

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Consultation for Medications in the Treatment of Obsessive-Compulsive Disorder (OCD)


Hello Dr.
Lin, I am 39 years old and have experienced obsessive-compulsive symptoms over the years, but I have never sought treatment from a psychiatrist until a few months ago when my mother passed away, which has deeply affected my life and mental state.
I am considering consulting a psychiatrist for treatment, but I had a cardiac catheterization in 2019 and had a drug-eluting stent placed.
I would like to provide you with my current medications for reference.
I have researched information regarding pharmacological treatments for obsessive-compulsive disorder (OCD), such as SSRIs, and it seems that these serotonin reuptake inhibitors may interact with cardiovascular medications (like aspirin) and increase the risk of bleeding.
Given my history of cardiovascular disease and current medications, how should I approach the choice of medication for treating OCD? After weighing the risks and benefits, if treating my OCD poses a greater risk of bleeding, such as intracranial hemorrhage or gastrointestinal bleeding, would it be better for me to remain in my current situation without taking action? Although obsessive thoughts affect my life, they do not incapacitate me to the extent that many others experience.
I would like to seek your professional advice on these issues.
Thank you for your help! Additionally, I have been experiencing insomnia over the past few months, and my cardiologist prescribed LOWEN TABLETS 0.5MG (LORAZEPAM) "C.C.P." for treatment, which has helped stabilize my sleep.
My current medications include: 1.
ULSTOP F.C.
TABLETS 20MG "C.H." (FAMOTIDINE) 2.
Nebilet 5 mg 3.
Sevikar 5/20mg film-coated tablets 4.
BOKEY ENTERIC-MICROENCAPSULATED CAPSULES 100MG (ASPIRIN) 5.
CRESTOR 5MG FILM-COATED TABLETS 6.
NORVASC TABLETS 5MG 7.
HERBESSER TABLETS 30MG 8.
MELETIN CAPSULES 100MG "S.T." (MEXILETINE) 9.
LOWEN TABLETS 0.5MG (LORAZEPAM) "C.C.P."

JJ, 30~39 year old female. Ask Date: 2022/12/17

Dr. Lin Mianzhang reply Psychiatry


Hello JJ: SSRIs do indeed increase the risk of bleeding, especially when combined with anticoagulants.
However, their use is not an absolute contraindication for individuals with cardiovascular or cerebrovascular diseases.
If a clinical assessment indicates the need for these medications, they can still be used, but regular monitoring of coagulation function is necessary.
If your obsessive-compulsive symptoms are not severe and you are concerned about the side effects of medication, you might consider starting with psychotherapy.
Exposure and Response Prevention (ERP) therapy is also recognized as a first-line treatment for obsessive-compulsive disorder, with effects comparable to medication, and the benefits can last longer.
Therefore, I recommend that you consult a mental health specialist to discuss appropriate treatment options.
Wishing you peace and health.

Reply Date: 2022/12/17

More Info


When considering the treatment of Obsessive-Compulsive Disorder (OCD) in patients with a history of cardiovascular disease, it is essential to approach the situation with caution and a thorough understanding of both the psychiatric and medical aspects involved. Your history of coronary artery disease, including a previous catheterization and the placement of a drug-eluting stent, necessitates a careful evaluation of any new medications, particularly those that may interact with your existing cardiovascular medications.

Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly prescribed for OCD and have been shown to be effective in reducing symptoms. However, as you mentioned, there is a concern regarding the potential for increased bleeding risk when SSRIs are used in conjunction with anticoagulants or antiplatelet medications, such as aspirin, which you are currently taking. This risk is particularly relevant for patients with a history of cardiovascular issues, as any bleeding complications could have serious consequences.

In your case, the following considerations should be taken into account:
1. Medication Interactions: SSRIs, while generally safe, can increase the risk of gastrointestinal bleeding, especially when combined with aspirin. It is crucial to discuss with your healthcare provider the specific SSRIs that may be appropriate for you, considering their safety profile and potential interactions with your current medications.

2. Alternative Treatments: If the risk of SSRIs is deemed too high, other treatment options for OCD can be explored. Cognitive Behavioral Therapy (CBT), particularly Exposure and Response Prevention (ERP), is a highly effective non-pharmacological treatment for OCD. This approach may be beneficial for you, especially since you mentioned that your symptoms, while distressing, are not debilitating.

3. Monitoring and Follow-Up: If you and your healthcare provider decide to proceed with pharmacological treatment, close monitoring will be essential. Regular follow-ups can help assess the effectiveness of the treatment and any potential side effects, including bleeding risks.

4. Lifestyle Modifications: In addition to medication and therapy, lifestyle changes can also play a significant role in managing both OCD and cardiovascular health. Regular physical activity, a balanced diet, and stress management techniques can contribute positively to your overall well-being.

5. Risk-Benefit Analysis: Ultimately, the decision to start medication should involve a thorough discussion with your healthcare provider about the potential benefits of treating your OCD against the risks associated with your cardiovascular history. If your OCD symptoms are manageable and not significantly impacting your quality of life, it may be reasonable to consider a conservative approach, focusing on therapy and lifestyle changes rather than immediate pharmacological intervention.

In conclusion, while the treatment of OCD in patients with a history of cardiovascular disease presents unique challenges, it is not insurmountable. A collaborative approach involving your primary care physician, cardiologist, and a psychiatrist or psychologist can help ensure that you receive the most appropriate care tailored to your specific needs. It is essential to communicate openly with your healthcare providers about your concerns and preferences, allowing them to guide you in making informed decisions regarding your treatment options.

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