Consulting on Cardiovascular Medications and Sleep Aids Safety - Cardiology

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Cardiovascular medication consultation


Hello, Director He.
I am 39 years old and underwent a cardiac catheterization procedure in 2019, during which a drug-eluting stent was placed.
I would like to provide you with the medications I am currently taking in the morning and evening for your reference.
In recent months, I have experienced insomnia and frequently wake up in the middle of the night and cannot fall back asleep, especially after the passing of my mother.
During a regular outpatient visit, my cardiologist prescribed LOWEN TABLETS 0.5MG (LORAZEPAM) "C.C.P." for treatment, which has helped me sleep more soundly at night.
However, I am concerned about the potential for dependence with long-term use.
Recently, I came across several dietary supplements that claim to aid sleep, one of which contains GABA, tryptophan, and approximately 6.7 mg (10 IU) of vitamin E.
I have read some information indicating that the concurrent use of vitamin E with aspirin or cardiovascular medications may increase the risk of bleeding.
I would like to ask you, Director He, whether this sleep aid supplement might interact with my current medications.
Will the addition of vitamin E increase the risk of bleeding? I hope to receive your professional advice on these matters.
Thank you for your assistance!
1.
ULSTOP F.C.
TABLETS 20MG "C.H." (FAMOTIDINE)
2.
Nebilet 5 mg
3.
Sevikar 5/20mg film-coated tablets
4.
BOKEY ENTERIC-MICROENCAPSULATED CAPSULES 100MG (ASPIRIN)
5.
CRESTOR 5MG FILM-COATED TABLETS
6.
NORVASC TABLETS 5MG
7.
HERBESSER TABLETS 30MG
8.
MELETIN CAPSULES 100MG "S.T." (MEXILETINE)
9.
LOWEN TABLETS 0.5MG (LORAZEPAM) "C.C.P."

JJ, 30~39 year old female. Ask Date: 2022/12/18

Dr. He Dongjin reply Cardiology


Hello, it actually doesn't have much impact.
It's more important to focus on getting through the present moment.
Dependency? Conflict? It really doesn't matter much, so don't worry.
Changhua Hospital cares about you.

Reply Date: 2022/12/18

More Info


When considering the interaction between cardiovascular medications and sleep aids, it is essential to evaluate both the pharmacological properties of the drugs involved and the potential risks associated with their combined use. In your case, you are currently taking a variety of medications for cardiovascular health, including aspirin, and have recently been prescribed lorazepam (Lowen Tablets) for sleep disturbances. Additionally, you are considering a sleep aid supplement that contains GABA, tryptophan, and vitamin E.


Interaction Between Lorazepam and Sleep Aids
Lorazepam is a benzodiazepine that is commonly prescribed for anxiety and sleep disorders. While it can be effective in promoting sleep, there is a concern regarding its potential for dependence, especially with long-term use. It is crucial to use lorazepam under the guidance of a healthcare provider, particularly given your history of cardiovascular issues.

The sleep aid supplement you are considering, which contains GABA and tryptophan, is generally regarded as safe. GABA is an inhibitory neurotransmitter that can promote relaxation and sleep, while tryptophan is an amino acid that serves as a precursor to serotonin, which can also aid in sleep regulation. However, the efficacy of these supplements can vary from person to person, and they may not be as potent as prescription medications like lorazepam.


Vitamin E and Cardiovascular Medications
Regarding the vitamin E component of the sleep aid, there is some evidence suggesting that high doses of vitamin E may increase the risk of bleeding, particularly when taken with anticoagulants or antiplatelet medications like aspirin. However, the amount of vitamin E in your supplement (6.7 mg or 10 IU) is relatively low and is unlikely to pose a significant risk when taken in conjunction with aspirin. The general recommendation is to monitor for any unusual bleeding or bruising if you decide to take this supplement.


Recommendations
1. Consult Your Healthcare Provider: Before adding any new supplements to your regimen, it is essential to discuss this with your cardiologist or primary care physician. They can provide personalized advice based on your complete medical history and current medications.

2. Monitor Your Symptoms: If you decide to try the sleep aid supplement, keep track of any changes in your sleep patterns, mood, or any side effects. This information can be valuable for your healthcare provider in assessing the effectiveness and safety of the supplement.

3. Consider Non-Pharmacological Approaches: In addition to medication, consider behavioral strategies for managing insomnia, such as cognitive-behavioral therapy for insomnia (CBT-I), relaxation techniques, and maintaining good sleep hygiene. These approaches can be effective and may reduce the need for pharmacological interventions.

4. Evaluate the Need for Lorazepam: If you are concerned about the long-term use of lorazepam, discuss this with your doctor. They may suggest tapering the dose or exploring alternative treatments for anxiety and sleep disturbances that carry a lower risk of dependence.

5. Stay Informed About Your Medications: Understanding the potential interactions and side effects of your medications can empower you to make informed decisions about your health. Always feel free to ask your healthcare provider about any concerns you have regarding your treatment plan.

In summary, while there may not be significant interactions between your current medications and the sleep aid supplement you are considering, it is crucial to approach any changes in your regimen with caution and under the guidance of your healthcare provider. Your health and safety should always be the top priority.

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