Switching from Etoposide to Aive: Managing Side Effects in Women's Health - Obstetrics and Gynecology

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Change from Eutirox to Aivei contraceptive pill?


I previously took Estrogen for over two years, but eventually, I started feeling unwell and often had headaches.
So, I consulted my gynecologist about switching to Yaz, and the doctor agreed.
However, after taking two packs of Yaz, I experienced frequent bleeding.
I then switched to Alesse, and initially, I also had bleeding, but it stopped around the 10th pill.
Unfortunately, towards the end of the second pack, the bleeding resumed, resembling a menstrual period.
I have been experiencing intermittent bleeding for about three months now.
I couldn't tolerate it anymore, so I went back to Estrogen, but this time, I felt very uncomfortable, with increased bleeding, blood clots, headaches, nausea, and hot flashes.
Can I finish one pack of Estrogen and then switch to Aviane?

Jiayi Nu, 30~39 year old female. Ask Date: 2023/01/10

Dr. Huang Yuande reply Obstetrics and Gynecology


It is common to experience some irregular bleeding when using hormone therapy, and it is generally recommended to continue the treatment as this may help stop the bleeding.
If a different medication is used midway, the body will need to readjust due to the different mechanisms of action, which can lead to further confusion.
Therefore, it is important to discuss this with a physician.

Reply Date: 2023/01/10

More Info


Switching from Etoposide (異位寧) to Aive (悅姿) or any other hormonal contraceptive can be a complex decision, especially when managing side effects and ensuring effective contraception. It’s essential to understand the implications of such a switch, particularly in the context of women's health.

Etoposide is primarily used as a chemotherapy agent, and its side effects can include nausea, vomiting, and fatigue, among others. On the other hand, Aive and similar hormonal contraceptives are designed to regulate menstrual cycles and prevent pregnancy, but they can also cause side effects such as breakthrough bleeding, headaches, and mood changes.

From your description, it seems that you have experienced significant side effects while on Etoposide, including increased bleeding and discomfort. After switching to Aive, you initially experienced some breakthrough bleeding, which is not uncommon when starting a new hormonal contraceptive. This bleeding can occur as your body adjusts to the new hormone levels. However, the fact that you have had prolonged bleeding for about three months is concerning and warrants further evaluation.

It is important to note that switching back to Etoposide after experiencing side effects from Aive may not be the best option, especially if you are experiencing increased bleeding and discomfort. The presence of blood clots and heavy bleeding can indicate a more serious underlying issue, such as hormonal imbalance or other gynecological conditions. Therefore, it is crucial to consult with your healthcare provider before making any changes to your medication regimen.

Regarding your question about switching to Aive after finishing a course of Etoposide, it is generally possible to transition between hormonal contraceptives, but it should be done under medical supervision. Your healthcare provider can help determine the best timing for the switch and monitor any potential side effects. They may also consider alternative contraceptive methods or additional treatments to manage your symptoms effectively.

In summary, while switching from Etoposide to Aive is feasible, it is essential to do so with the guidance of your healthcare provider. They can help assess your current symptoms, evaluate the underlying causes of your bleeding, and recommend the most appropriate contraceptive method for your situation. Additionally, if you continue to experience significant side effects or irregular bleeding, further investigation may be necessary to rule out any other health issues. Always prioritize open communication with your healthcare provider to ensure that your treatment plan aligns with your health needs and lifestyle.

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