Antipsychotic Medications: Myths, Risks, and Treatment Options - Psychiatry

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Psychiatric medications


I have read a book about schizophrenia that states long-term use of psychiatric medications can lead to birth defects, and that schizophrenia is hereditary.
How credible is this information? I have been taking my medication regularly for three months without any relapse.
Is there a chance I could stop taking the medication in the future? There are two different opinions on this matter.
Are they true? I am in Taoyuan; can you recommend a more specialized hospital or doctor? I am currently receiving treatment at a local clinic, but they cannot address this issue.
Thank you.
(Does taking 200 mg of Seroquel daily lead to diabetes?) I feel overwhelmed.
Thank you.
(I have trouble getting up in the morning and want to change my medication.)

Chen, 20~29 year old female. Ask Date: 2003/11/10

Dr. Tang Xinbei reply Psychiatry


Dear friend: There are many types of psychiatric medications, and past research has shown that only a very small number may potentially cause fetal malformations, and only if the patient is the mother and has taken a significant amount of psychiatric medication during the first three months of pregnancy.
Generally speaking, patients who are on long-term medication should discuss their plans with their treating physician before attempting to conceive.
If possible, it is safer to try to conceive after discontinuing the medication.
Previously, I mentioned that current literature and research reports indicate that Seroquel does not cause diabetes! Under long-term treatment, this medication is relatively safe and does not have significant effects on kidney and liver function.
As for the possibility of recovery to the point where medication is no longer needed, current research and literature suggest that long-term medication is recommended! If you are experiencing some side effects from this medication, I still recommend discussing whether to switch medications or adjust the dosage with your treating physician.
Additionally, besides Taoyuan Hospital, there are psychiatric departments at Taoyuan Veterans Hospital, Min-Sheng Hospital, Ju-Shan Hospital, and Linkou Chang Gung Memorial Hospital nearby, where you can also inquire.
Wishing you peace and joy!

Reply Date: 2003/11/10

More Info


Understanding antipsychotic medications, particularly in the context of schizophrenia, involves navigating a landscape filled with both facts and myths. Your concerns about the long-term effects of these medications, the hereditary nature of schizophrenia, and the potential for stopping medication are all valid and deserve careful consideration.

First, regarding the claim that long-term use of antipsychotic medications can lead to birth defects, it is important to clarify that while some studies have suggested that certain antipsychotics may carry risks during pregnancy, the overall risk of congenital malformations is relatively low. However, it is crucial for women who are pregnant or planning to become pregnant to discuss their medication regimen with their healthcare provider. The benefits of treating a mental health condition must be weighed against the potential risks to the fetus.
As for the hereditary aspect of schizophrenia, research indicates that genetics do play a role in the development of the disorder. Individuals with a family history of schizophrenia are at a higher risk of developing the condition themselves. However, it is not a straightforward inheritance pattern; environmental factors and individual circumstances also significantly contribute to the risk.

You mentioned that you have been taking your medication regularly for three months without any relapse. This is a positive sign, as adherence to medication is crucial in managing schizophrenia. The possibility of stopping medication depends on various factors, including the stability of your condition, the presence of any side effects, and the recommendations of your healthcare provider. Some individuals may eventually taper off their medications under medical supervision, while others may need to continue treatment long-term to maintain stability.

Regarding your concern about Seroquel (quetiapine) and its potential link to diabetes, it is known that some atypical antipsychotics, including Seroquel, can lead to metabolic side effects, including weight gain and changes in glucose metabolism. This does not mean that everyone who takes Seroquel will develop diabetes, but it is a risk factor that should be monitored. Regular check-ups that include monitoring weight, blood sugar levels, and lipid profiles are essential for anyone on these medications.

If you are feeling overwhelmed or unsure about your treatment, it is crucial to communicate openly with your healthcare provider. They can help address your concerns, adjust your medication if necessary, and provide support. If you feel that your current treatment facility is not meeting your needs, seeking a second opinion or consulting with a specialist in a larger hospital or mental health facility may be beneficial. In Taoyuan, there are several reputable hospitals and clinics that specialize in psychiatric care. It may be helpful to ask for referrals from your current healthcare provider or to look for mental health professionals who have experience with schizophrenia and antipsychotic medications.

Lastly, if you are experiencing significant side effects or if your current medication regimen is not working for you, it is essential to discuss these issues with your doctor. They can help you explore alternative medications or therapies that may be more suitable for your situation. Remember, managing mental health is a collaborative process, and your input is vital in finding the best treatment plan for you.

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