Does Cefixmycin Affect Birth Control Pills? Drug Interactions - Obstetrics and Gynecology

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Drug interactions


Hello doctor, I would like to ask if the medication Cefixmycin has any effects on birth control pills.
Thank you for your response!

Niming, 10~19 year old female. Ask Date: 2023/01/24

Dr. Zhang Kunmin reply Obstetrics and Gynecology


Hello, the following medications may interact with oral contraceptives:
1.
Antibiotics (Penicillin, Cephalosporins, Erythromycin, Sulfonamides, Bactrim, Chloramphenicol, Doxycycline) can reduce the effectiveness of oral contraceptives.
When taking these medications, alternative contraceptive methods should be used, as they may decrease the gut flora that aids in absorption, thereby lowering the effectiveness of the contraceptive.
2.
Sedatives (Barbiturates) can increase the metabolism of oral contraceptives, reducing their effectiveness.
3.
Antiepileptic drugs (Primidone, Phenytoin, Carbamazepine) can also increase the metabolism of oral contraceptives, leading to decreased effectiveness.
4.
Tuberculosis medications (Rifampicin, Isoniazid).
5.
Antidiabetic medications (Rosiglitazone).
6.
Acetaminophen and Ascorbic acid (Vitamin C) may inhibit estrogen metabolism, potentially increasing its concentration in the body and leading to a higher incidence of side effects.
7.
Oral contraceptives can affect the action of anticoagulants.
8.
Smoking can increase the metabolism of oral contraceptives, reducing their effectiveness.
9.
Long-term consumption of tea or certain herbs may have additive or subtractive effects with oral contraceptives.
Additionally, any medication should be taken with water and not with beverages like tea or coffee, as this may affect the medication's efficacy.
If you are taking any of the mentioned medications, it is advisable to use additional contraceptive measures for seven days.
Thank you! Wishing you peace and health.
Dr.
Zhang.

Reply Date: 2023/01/24

More Info


Cefixmycin is a cephalosporin antibiotic used to treat various bacterial infections. When considering its interaction with oral contraceptives, it is essential to understand how certain medications can affect the efficacy of birth control pills.
Research indicates that some antibiotics can potentially reduce the effectiveness of hormonal contraceptives. This is primarily due to the impact these antibiotics may have on the gut flora, which plays a crucial role in the metabolism and absorption of the hormones present in birth control pills. Specifically, antibiotics like rifampicin and certain other medications have been shown to significantly lower the effectiveness of oral contraceptives.
However, cefixime, which is closely related to cefixmycin, does not have a well-documented interaction with birth control pills. The consensus among healthcare professionals is that while some antibiotics may pose a risk to the effectiveness of hormonal contraceptives, cefixmycin is generally not considered to have a significant impact. Nevertheless, it is always prudent to take extra precautions, such as using a backup contraceptive method, when taking any antibiotic, especially if you are concerned about potential interactions.

It is also important to note that while cefixmycin itself may not directly affect the efficacy of birth control pills, other factors can contribute to reduced contraceptive effectiveness. For instance, gastrointestinal issues such as vomiting or diarrhea, which can occur with antibiotic use, might impair the absorption of the contraceptive hormones. Therefore, if you experience any gastrointestinal disturbances while taking cefixmycin, it is advisable to consult your healthcare provider regarding your contraceptive method.

In summary, while cefixmycin is not typically associated with a significant reduction in the effectiveness of oral contraceptives, it is always best to err on the side of caution. If you are prescribed cefixmycin and are using birth control pills, consider discussing with your healthcare provider about additional contraceptive measures to ensure continued protection against unintended pregnancy. Always keep an open line of communication with your healthcare provider regarding any medications you are taking and their potential interactions.

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