Stomach Ulcers and Submucosal Tumors: Key Insights - Gastroenterology and Hepatology

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Gastric ulcer and submucosal tumors of the stomach?


Hello Doctor, during the company health check, my gastric cancer index was 96.
Later, I underwent an endoscopy and colonoscopy, which revealed a gastric ulcer and a 2 cm submucosal tumor in the stomach.
The doctor prescribed Nexium (esomeprazole) and Duspatalin (mebeverine) for me.
I have been experiencing severe diarrhea, especially in the morning upon waking or after meals.

1.
Should I take Nexium first thing in the morning and wait an hour before eating?
2.
Is it necessary to remove the 2 cm submucosal tumor in the stomach? I have an ultrasound surgery scheduled for February 21.
After the removal, what should I pay attention to? How long after the surgery can I return to normal work? Thank you, Doctor.

Xiang, 30~39 year old female. Ask Date: 2023/02/03

Dr. Lin Minghui reply Gastroenterology and Hepatology


1.
Proton pump inhibitors are recommended to be taken 30 to 60 minutes before breakfast for optimal effect.

2.
If a submucosal tumor of the stomach is a gastrointestinal stromal tumor (GIST) larger than 2 cm, endoscopic or laparoscopic surgical resection is advised.
Submucosal tumors of the stomach may arise from organ compression or may be tumors originating from the gastrointestinal tract itself, such as leiomyomas, lipomas, stromal tumors, neuroendocrine tumors, or ectopic pancreatic tissue.
Endoscopic ultrasound and biopsy may sometimes be performed for diagnostic evaluation of submucosal tumors.
Most submucosal tumors are monitored, but if a GIST or larger submucosal tumor exceeds 2 cm and presents with symptoms such as bleeding or obstruction, surgical removal is recommended.

3.
Due to uncertainties regarding the surgical procedure, it may be necessary to consult with the surgical team or refer to the preoperative and postoperative instructions in the surgical consent form.
Wishing you good health!

Reply Date: 2023/02/03

More Info


When it comes to stomach ulcers and submucosal tumors, it is essential to understand the implications of these conditions, their management, and the necessary follow-up care. Based on your situation, where you have been diagnosed with a stomach ulcer and a 2 cm submucosal tumor, let's break down your questions and provide a comprehensive overview.

1. Medication Timing and Administration: You mentioned taking "耐適恩" (likely referring to a proton pump inhibitor) in the morning. It is generally recommended to take proton pump inhibitors (PPIs) on an empty stomach, typically 30 to 60 minutes before breakfast. This allows the medication to effectively reduce stomach acid production, which is crucial for healing ulcers. After taking the medication, waiting for about an hour before eating is advisable, as this maximizes the drug's effectiveness.

2. Management of Submucosal Tumors: The presence of a 2 cm submucosal tumor raises several considerations. Not all submucosal tumors require surgical intervention; the decision to remove the tumor often depends on various factors, including its characteristics (such as size, growth pattern, and histological type), symptoms, and potential for malignancy. In your case, since a surgical procedure has already been scheduled, it suggests that your healthcare team has determined that removal is necessary, likely due to concerns about the tumor's nature or its potential impact on your health.

3. Postoperative Care and Recovery: After the surgical removal of a submucosal tumor, there are several important considerations:
- Monitoring for Complications: After surgery, it is crucial to monitor for any signs of complications, such as bleeding, infection, or issues related to the surgical site. Your healthcare provider will give you specific instructions on what to watch for.

- Dietary Adjustments: Initially, you may need to follow a soft or liquid diet to allow your stomach to heal. Gradually, you can reintroduce solid foods as tolerated.

- Activity Restrictions: Depending on the extent of the surgery, your doctor will provide guidelines on when you can return to normal activities, including work. Generally, patients may need a few days to a couple of weeks off work, depending on how they feel and the nature of their job.

- Follow-Up Appointments: Regular follow-up appointments are essential to monitor your recovery and to ensure that the ulcer and any other gastrointestinal issues are being managed effectively.

4. Understanding Your Condition: Stomach ulcers, also known as peptic ulcers, are sores that develop on the lining of the stomach or the upper part of the small intestine. They can be caused by factors such as Helicobacter pylori infection, long-term use of NSAIDs, excessive alcohol consumption, and stress. Submucosal tumors, on the other hand, can be benign or malignant growths that arise from the layers of the stomach wall. The management of these conditions often involves a combination of medication (like PPIs for ulcers) and surgical intervention for tumors.

In summary, it is vital to adhere to your doctor's instructions regarding medication, follow up on your scheduled surgery, and maintain open communication with your healthcare team. They will provide the best guidance tailored to your specific situation, ensuring that you receive appropriate care and monitoring throughout your treatment journey. Always feel free to ask your healthcare provider any questions or express concerns you may have about your condition or treatment plan. Your health and well-being should always be the priority.

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