Impact of Dairy Products on Antibiotic Efficacy in Urology Treatments - Urology

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Antibiotics and Dairy Products


Hello, due to the inability to ask questions regarding medication consultation, I am inquiring about a urological issue.
I have been experiencing a slight irritation at the urethral opening during urination, and there is a noticeable irritation when there is a residual 1-2 drops at the urethral opening, although there are no significant abnormalities elsewhere.
I consulted a physician who suspected a Chlamydia infection and prescribed DOXYCYCLINE 100 MG to be taken twice daily after meals, DICLOFENAC 25 MG to be taken twice daily after meals, and PHENAZOPYRIDINE 100 MG to be taken twice daily after meals.
I have a long-standing habit of taking probiotics before bed, but I did not realize that the probiotics contained dairy (I found out after inquiring with the manufacturer).
Therefore, I took the probiotics for the first two days of the treatment before bed, but there was a 5-6 hour gap after dinner before taking the medication.
Will this affect the efficacy of the antibiotic? Could it lead to antibiotic resistance in the bacteria?

Niming, 20~29 year old female. Ask Date: 2023/02/06

Dr. Du Shixi reply Urology


Hello: It should not be a concern, as long as you take the medication as prescribed.
Not taking it on time or stopping the medication could potentially lead to drug resistance.
Wishing you good health.

Reply Date: 2023/02/06

More Info


The question regarding the impact of dairy products on the efficacy of antibiotics, particularly in the context of urology treatments, is an important one. In your case, you are taking Doxycycline, which is a tetracycline antibiotic commonly used to treat various bacterial infections, including those caused by Chlamydia, which your doctor suspects. You also mentioned taking Phenazopyridine for urinary discomfort and Diclofenac for pain relief.

Dairy products can indeed affect the absorption of certain antibiotics, particularly tetracyclines like Doxycycline. The calcium in dairy can bind to the antibiotic in the gastrointestinal tract, forming an insoluble complex that reduces the amount of the drug that is absorbed into the bloodstream. This can potentially lead to decreased effectiveness of the antibiotic. However, the timing of when you consume dairy products in relation to when you take your medication is crucial.
In your case, since you mentioned that you took the probiotic containing dairy products several hours after your antibiotic dose, the impact on Doxycycline's absorption should be minimal. It is generally recommended to avoid dairy products within two hours before and after taking Doxycycline to ensure optimal absorption. Since you waited 5-6 hours after your last meal before taking the probiotic, it is unlikely that the dairy would have significantly interfered with the antibiotic's efficacy.

Regarding the concern about antibiotic resistance, it is important to use antibiotics judiciously. Taking antibiotics when they are not needed, or not completing a prescribed course, can contribute to the development of antibiotic-resistant bacteria. However, if you are taking the antibiotic as prescribed for a confirmed bacterial infection, and if you are following the guidelines for its use, the risk of developing resistance is minimized.
In addition to the potential interaction with dairy, it is also worth noting that probiotics can be beneficial during and after antibiotic treatment. They can help restore the natural balance of gut flora that may be disrupted by antibiotic use. However, it is advisable to take probiotics at a different time than your antibiotics to maximize their effectiveness.

In summary, based on the information provided, the dairy in your probiotic should not significantly affect the efficacy of Doxycycline, especially given the time interval between taking the antibiotic and the probiotic. It is essential to follow your healthcare provider's instructions regarding medication and to communicate any concerns you have about your treatment. If you continue to experience symptoms or have further questions about your treatment plan, it is advisable to follow up with your healthcare provider for personalized advice.

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