Tuberculosis Transmission and Risks in Family Members - Pulmonology

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Questions related to pulmonary tuberculosis?


Hello, Doctor! My father was diagnosed with open pulmonary tuberculosis in 2020 and was hospitalized for nearly a year for treatment.
After that, both my mother and my daughter tested positive and received preventive medication.
I, myself, had negative results for tuberculosis bacteria in blood tests, chest X-rays, and sputum tests, but a shadow was detected in my lungs, so I subsequently paid for a CT scan.
At the end of last year, the shadow on the X-ray and the CT scan showed signs of possible enlargement, so the doctor requested another sputum test.
This time, the report indicated the presence of tuberculosis bacteria, classified as open and contagious, requiring treatment.
I would like to ask, given that it has been so long since my father's diagnosis, was I infected at that time? I don't understand why nothing was detected during the follow-up period, and why it only became classified as open tuberculosis after the recent tests.
Additionally, I would like to know if my daughter is at risk of a second diagnosis, considering she has already been on medication for 9 months.
If someone else in the household falls ill at different times, will young children continuously face the risk of needing medication? The medication is really difficult to take and harmful to health, and I am very concerned about the potential risks for my child.
Thank you, Doctor, for your answers!

Megan, 30~39 year old female. Ask Date: 2023/02/07

Dr. Huang Yiwen reply Pulmonology


Dear Megan: In 2020, your father had tuberculosis, so it is most likely that he was the source of transmission.
Tuberculosis is primarily transmitted within households.
Currently, the incidence rate in Taiwan has decreased to 31 per 100,000.
The chance of contracting it from outside sources is very low.
Blood tests can still yield a slight false negative.
After completing the treatment, there is no need for further medication, as blood tests are no longer reliable (unless using specific values).
The risk of developing the disease is relatively low, but regular check-ups are still necessary for two years.
Changhua Hospital cares about you.

Reply Date: 2023/02/07

More Info


Understanding tuberculosis (TB) transmission and the associated risks within a family setting is crucial, especially when there is a history of active TB cases. In your situation, where your father was diagnosed with open tuberculosis in 2020 and you have undergone various tests, it is understandable to have concerns about potential transmission and the health of your family members, particularly your daughter.

Firstly, it is important to clarify the nature of tuberculosis. TB is primarily an airborne infectious disease caused by the bacterium Mycobacterium tuberculosis. It is transmitted when an infected person coughs, sneezes, or talks, releasing droplets that contain the bacteria into the air. However, not everyone who is exposed to the bacteria will become infected. In fact, many individuals may develop latent TB infection (LTBI), where the bacteria remain inactive in the body and do not cause symptoms or spread to others.
In your case, the fact that you tested negative for TB through blood tests, chest X-rays, and sputum tests initially suggests that you were not actively infected at that time. However, the subsequent discovery of TB bacteria in your sputum indicates that you have developed active TB, which is indeed contagious. The delay in diagnosis can be attributed to several factors, including the possibility of the bacteria being in a dormant state initially or the limitations of the tests used during your earlier evaluations.
As for your daughter, since she has already undergone preventive treatment for nine months, her risk of developing active TB is significantly reduced. However, it is essential to monitor her closely, especially if there are any new exposures or if she exhibits any symptoms suggestive of TB, such as a persistent cough, weight loss, or night sweats. The risk of reinfection or developing active TB after treatment is generally low, but it is not zero, particularly if there are ongoing exposures to active cases within the household.

Regarding the concern about other family members developing TB, it is indeed possible for multiple individuals in a household to be affected, especially if there are repeated exposures to an active case. In such scenarios, preventive treatment may be necessary for those who are at higher risk, particularly young children or individuals with weakened immune systems. The decision to initiate preventive therapy should be made in consultation with a healthcare provider, who can assess the risks and benefits based on the specific circumstances of each family member.

It is also worth noting that the medications used to treat TB can have side effects, and the taste of the medication can be challenging, especially for children. However, the benefits of treatment in preventing severe illness and complications from TB far outweigh the temporary discomfort associated with the medication.
In summary, while the risk of transmission within a household with a history of TB is significant, proper screening, preventive treatment, and monitoring can effectively manage this risk. It is crucial to maintain open communication with healthcare providers, adhere to treatment plans, and ensure regular follow-ups to safeguard the health of all family members. If you have further concerns or if new symptoms arise, do not hesitate to seek medical advice promptly.

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