the Components of +E Anesthesia and Its Effects - Anesthesiology

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+E anesthetic components


I would like to know the components of +E anesthetic (it is said that it causes less bleeding).
I previously experienced increased heart rate and cold sweats about an hour after receiving it, but the clinic from years ago is unclear about it.
Therefore, I would like to know what kind of tests I should undergo.
Thank you for your professional response, doctor.

Ms. B, 30~39 year old female. Ask Date: 2023/02/13

Dr. Huang Baiqing reply Anesthesiology


Hello Ms.
B: I assume that your "+E anesthetic" refers to a local anesthetic that contains "epinephrine." This is widely used by physicians across various specialties in clinical practice to prolong the duration of the local anesthetic's effect.
This allows physicians to perform procedures or treatments that may cause pain or discomfort in a single session without interruption due to the local anesthetic wearing off and the patient experiencing pain.

When any medication is injected into local tissues, a small amount may inadvertently enter the bloodstream.
If "epinephrine" enters the bloodstream, it can lead to symptoms such as increased heart rate, elevated blood pressure, cold sweats, and even headaches.
Therefore, your mention of experiencing such symptoms in the past does not require any testing, as this is indeed a possible occurrence in any individual.

I recommend that you inform the physician performing the procedure or treatment about your previous discomfort before receiving the "+E local anesthetic" next time.
I believe they will know how to minimize the likelihood of such occurrences and will pay extra attention to your situation.

Reply Date: 2023/02/13

More Info


The "+E anesthesia" you are referring to is likely a local anesthetic that contains epinephrine (also known as adrenaline). This combination is commonly used in various medical procedures to prolong the effects of the local anesthetic and minimize bleeding during surgery. The addition of epinephrine constricts blood vessels in the area where the anesthetic is applied, which helps to reduce blood flow and prolong the duration of anesthesia.

When epinephrine is injected into the body, especially if it inadvertently enters the bloodstream, it can lead to several physiological responses. The symptoms you experienced—such as increased heart rate (tachycardia), cold sweats, and possibly anxiety—are consistent with the effects of epinephrine. This is because epinephrine is a sympathomimetic agent, meaning it stimulates the sympathetic nervous system, which is responsible for the "fight or flight" response. This response can lead to an increase in heart rate, blood pressure, and other symptoms like sweating.

Regarding your question about testing, if you are concerned about the effects of the +E anesthesia you received in the past, it is essential to communicate your previous experiences to your healthcare provider. They may not require specific tests unless there are ongoing symptoms or concerns about your cardiovascular health. If you are experiencing persistent symptoms such as palpitations or anxiety, your doctor may recommend an electrocardiogram (ECG) or other cardiovascular assessments to ensure your heart is functioning correctly.

In terms of future procedures, it is crucial to inform your anesthesiologist or the physician administering the local anesthetic about your past reactions. They can take precautions, such as using a lower concentration of epinephrine or opting for a different anesthetic that does not contain epinephrine, to minimize the risk of similar side effects.

In summary, the +E anesthesia you mentioned contains epinephrine, which can cause increased heart rate and other sympathetic nervous system effects if it enters the bloodstream. If you have concerns about your health or previous reactions, discussing these with your healthcare provider is the best course of action. They can provide personalized advice and ensure that your future medical treatments are safe and effective.

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