Uvula Lesions: Biopsy Results and Infection Risks - Otolaryngology

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Tumor Biopsy Report


Hello Doctor, I recently discovered a protrusion on my uvula.
Upon closer inspection, it didn't seem too different, but out of concern, I decided to undergo surgery for a biopsy.
I would like to ask the following questions: 1.
Does the report indicate a papilloma? 2.
If it does, what is the risk of transmission through kissing (since I had already been kissing before the discovery)? 3.
I have now had the tissue removed; if I recover and kiss someone again, will the risk of transmission be lower?
Oropharynx, uvula, left, laser excision, (1) squamous epithelial hyperplasia, (2) lymphoid hyperplasia.
Description: The specimen submitted consists of 1 tissue fragment measuring 0.3x0.3x0.3 cm in size, fixed in formalin.
Grossly, it is whitish and elastic.
All for section and labeled as A1; Jar: 0.
Microscopically, the section shows polypoid mucosa with squamous epithelial hyperplasia and lymphoid aggregates in the stroma.
Immunohistochemical study for cytokeratin reveals no evidence of occult carcinoma cells.

Maike, 30~39 year old female. Ask Date: 2023/02/16

Dr. Zheng Jueyi reply Otolaryngology


The report indicates epithelial hyperplasia and lymphoid tissue hyperplasia, rather than a papilloma.

Reply Date: 2023/02/16

More Info


Based on your inquiry regarding the biopsy results of your uvula lesion and the associated risks of transmission through kissing, let's break down the findings and address your concerns.


Understanding the Biopsy Results
Your biopsy results indicate two main findings: squamous epithelial hyperplasia and lymphoid hyperplasia.
1. Squamous Epithelial Hyperplasia: This condition refers to an increase in the number of squamous cells, which are flat cells that make up the outer layer of the skin and mucous membranes. This hyperplasia can occur due to irritation or inflammation but is not indicative of cancer.
2. Lymphoid Hyperplasia: This refers to an increase in lymphoid tissue, which is part of the immune system. It often occurs in response to infection or inflammation.
The report also states that there is no evidence of occult carcinoma cells, which means that there are no hidden cancer cells present in the tissue sample. Therefore, the findings do not suggest a papilloma (a type of benign tumor) or malignancy, but rather a benign reactive process.


Transmission Risks through Kissing
Now, regarding your concerns about transmission through kissing:
1. Transmission of HPV: If you were worried about a condition like a papilloma or HPV (human papillomavirus), it is important to note that while HPV can be transmitted through intimate skin-to-skin contact, including oral sex, the risk of transmission through kissing is generally considered low. Most oral HPV infections do not lead to significant health issues and often resolve on their own.

2. Current Status Post-Excision: Since you have had the lesion excised and the biopsy results are benign, the risk of transmitting any infection through kissing is significantly reduced. Once the area has healed completely, and if there are no active lesions or symptoms, the likelihood of transmission is minimal.

3. Healing Process: It is crucial to allow adequate time for healing after any surgical procedure. Engaging in kissing or other intimate contact before the area has fully healed could potentially introduce bacteria or irritate the site, leading to complications.

Recommendations
- Follow-Up Care: Ensure you follow your healthcare provider's recommendations regarding post-operative care. This may include avoiding certain activities until the area has healed completely.

- Monitor Symptoms: Keep an eye on any new symptoms that may arise after the procedure. If you notice any unusual changes, such as persistent pain, swelling, or discharge, consult your healthcare provider.

- Discuss with Your Doctor: If you have ongoing concerns about HPV or other sexually transmitted infections, consider discussing these with your healthcare provider. They can provide guidance on testing and preventive measures, such as vaccination against HPV.

In summary, your biopsy results indicate a benign condition, and the risk of transmission through kissing is low, especially after healing. Always prioritize communication with your healthcare provider for personalized advice and follow-up care.

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