Post-Surgery Follow-Up for Lung Adenocarcinoma: Key Considerations - Pulmonology

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Follow-up for Lung Adenocarcinoma


Hello Dr.
Huang, I underwent a thoracoscopic surgery this month to remove a 0.6 cm ground-glass nodule, which was diagnosed as lung adenocarcinoma (Acinar type).
The doctor recommended some follow-up: 1.
Schedule an MRI with contrast for the brain (gadolinium contrast agent) and a whole-body PET scan (radiation dose approximately 10 mSv) in May this year.
2.
After that, follow-up with a standard chest CT every three months (radiation approximately 7 mSv).
Since I am relatively young, I am uncertain how to weigh a) the long-term accumulation of radiation exposure versus b) the risk of lung cancer recurrence.
I would like to ask: 1.
Is the MRI of the brain and whole-body PET scan necessary, and what are the risks of not doing them? 2.
Can the postoperative follow-up be changed to LDCT (out-of-pocket)? Thank you! [Medical History] 12/2021: LDCT revealed a 0.7 cm ground-glass opacity in the right lower lobe.
12/2022: Standard chest CT (without contrast): 0.7 cm ground-glass opacity persisted in the right lower lobe.
02/2023: Thoracoscopic surgery performed, pathology report confirmed lung adenocarcinoma (actual size 0.6 x 0.6 x 0.4 cm).
Gross Description Specimen A: Specimen: Lung Specimen size: 5.5 x 3.0 x 2.5 cm Tumor Site: Periphery Tumor Size: Solitary, 0.6 x 0.6 x 0.4 cm Tumor gross configuration: Ill-defined, gray-white, elastic Pleural retraction: not identified Obstructive pneumonia: not identified Specimen B: group 3&4 lymph node, 0.4 x 0.4 x 0.4 cm Representative sections are taken and labeled as: A1, B1: tumor B1: group 3&4 lymph node Microscopic Diagnosis: Adenocarcinoma, Acinar, low-grade: 100% Tumor Size: Solitary, 0.6 x 0.6 x 0.4 cm Histological Grade: G2: Moderately differentiated: Acinar or papillary-predominant with no or <20% high-grade pattern Section Margin: Lung uninvolved Lymphovascular Invasion: Not present Visceral Pleural Invasion: The tumor does not invade the visceral pleura (PL0).
Spread Through Air Spaces: Not identified Pathologic Staging (pTNM) (AJCC 8th edition) Primary Tumor (T): T1a: Tumor <= 1 cm in greatest dimension Lymph Nodes (N): N0: No regional lymph node metastasis N2 (Number involved / Number examined) Right group 3&4: 0 / 1 Distant Metastasis (M): MX: Cannot be assessed Treatment Effect: No known presurgical therapy Comment: The small tumor is highlighted by TTF-1 and focally weakly positive for ROS-1, while negative for BRAF V600E immunostains.

Jay, 30~39 year old female. Ask Date: 2023/02/26

Dr. Huang Yiwen reply Pulmonology


Dear Jay: After undergoing a PET scan, if the findings are limited to the lungs, there is no need for frequent follow-up chest X-rays.
For the first two years, a CT scan should be performed every six months, and thereafter, further imaging will be based on necessity.
Changhua Hospital is concerned about you.

Reply Date: 2023/02/26

More Info


Post-surgery follow-up for lung adenocarcinoma is a critical aspect of patient management, particularly given the potential for recurrence. In your case, having undergone a thoracoscopic surgery to remove a 0.6 cm ground-glass nodule diagnosed as lung adenocarcinoma, it is essential to consider the recommendations for follow-up imaging and the associated risks and benefits.


1. Importance of MRI and Whole Body PET Scans
The recommendation for a brain MRI and a whole-body PET scan post-surgery is based on the need to ensure that there is no metastasis or recurrence of cancer. While your tumor was small (T1a, N0), and there was no lymph node involvement, the nature of lung cancer necessitates vigilance.
- MRI of the Brain: This imaging is particularly important because lung cancer can metastasize to the brain. Although the risk is lower for smaller tumors, it is not negligible. If you choose not to undergo this imaging, you may miss early signs of brain metastasis, which could significantly impact treatment options and outcomes.

- Whole Body PET Scan: This scan is more sensitive than CT in detecting metabolically active tumors. It can help identify any distant metastasis that may not be visible on other imaging modalities. The radiation dose from a PET scan is higher than that of a standard chest CT, but it provides critical information that can guide further management.


2. Risks of Not Performing Recommended Imaging
If you decide against these imaging studies, you may face several risks:
- Undetected Recurrence: Without thorough imaging, there is a chance that a recurrence or metastasis could go unnoticed, potentially leading to a more advanced stage of cancer by the time it is detected.

- Limited Treatment Options: Early detection of recurrence often allows for more effective treatment options. If cancer is allowed to progress, treatment may become more complex and less effective.


3. Consideration of LDCT for Follow-Up
Regarding your question about using Low-Dose CT (LDCT) for follow-up instead of standard chest CT, this is a reasonable consideration, especially given your age and the desire to minimize radiation exposure. LDCT is effective for lung cancer screening and follow-up, particularly in patients at risk.
- Radiation Exposure: LDCT significantly reduces radiation exposure compared to conventional CT scans. If you can afford the out-of-pocket expense, it may be a wise choice for your follow-up imaging.

- Follow-Up Protocol: The standard follow-up protocol typically involves imaging every three to six months for the first two years, then annually thereafter, depending on the risk factors and the oncologist's recommendations.


Conclusion
In summary, while the decision to proceed with MRI and PET scans involves weighing the benefits of early detection against the risks of radiation exposure, the potential for undetected recurrence makes these imaging studies valuable. If you are concerned about radiation, discussing the option of LDCT with your healthcare provider could be beneficial. Ultimately, maintaining open communication with your oncologist about your concerns and preferences will help tailor a follow-up plan that aligns with your health needs and personal values. Regular follow-up is crucial in managing lung adenocarcinoma, and being proactive in your care can significantly impact your long-term outcomes.

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