Elevated Mono Levels and Lymph Node Swelling: What to Know - Internal Medicine

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Infection-related issues?


Hello Doctor, I have some questions I would like to ask you: Current situation: 1) During a recent blood test, it was found that my monocyte count was above the normal range (normal is under 10, and my count was around 11; all other blood cell values were normal).
Additionally, since last summer, I have had several blood tests, and each time my monocyte count has been slightly higher than the previous one.
2) Two months ago, I discovered that I had multiple enlarged lymph nodes in both groin areas (some are small and round, while others are elongated, about a little over 1 cm).
I visited a general surgeon, who upon examination stated that they are just enlarged and not adhered to surrounding tissues, and advised me to return if they increase in size.
I would like to ask if this indicates an infection? Because aside from feeling a bit more fatigued lately (not sure if it's due to lack of sleep), I don't have any other symptoms.
Should I undergo any further tests? Thank you!

Niming, 20~29 year old female. Ask Date: 2023/03/01

Dr. Lin Wufu reply Internal Medicine


Hello: 1.
The total count of monocytes is typically assessed based on the total white blood cell count and the percentage they represent, as looking at the percentage alone may not provide an accurate assessment.
2.
If there is only swelling in the groin area, it is important to first evaluate for any infections in the lower extremities or related infections in the reproductive or urinary tract.
It is recommended to consult an infectious disease specialist for further evaluation.

Reply Date: 2023/03/01

More Info


Elevated mono levels and lymph node swelling can be concerning, and it's understandable that you have questions about your current health situation. Let's break down the information you provided and discuss what it might mean.

1. Elevated Mono Levels: The term "mono" typically refers to mononucleosis, which is often caused by the Epstein-Barr virus (EBV). Your mono levels being slightly elevated (11, while normal is under 10) could indicate a mild viral infection or a response to some other underlying condition. It's important to note that mono levels can fluctuate, and a gradual increase over time, as you've experienced, may suggest a persistent viral infection or an immune response to something else.
2. Lymph Node Swelling: The presence of swollen lymph nodes, particularly in the groin area, is often a sign that your body is responding to an infection or inflammation. Lymph nodes can swell due to various reasons, including viral infections, bacterial infections, or even more serious conditions like lymphoma. The fact that your doctor found no adhesion during the examination is a positive sign, as it suggests that the lymph nodes are likely reactive rather than indicative of a malignancy.

3. Symptoms: You mentioned feeling more fatigued than usual, which could be related to several factors, including sleep deprivation or the body's response to an ongoing infection. Fatigue is a common symptom associated with viral infections, including those caused by EBV.

4. Next Steps: Given your elevated mono levels and the swollen lymph nodes, it would be prudent to follow up with your healthcare provider. They may recommend further testing, such as:
- Repeat Blood Tests: To monitor your mono levels and check for other markers of infection or inflammation.

- Imaging Studies: If the lymph nodes continue to enlarge or if new symptoms develop, imaging studies like an ultrasound or CT scan may be warranted to assess the lymph nodes more closely.

- Biopsy: In rare cases, if there is significant concern about the nature of the lymph nodes, a biopsy may be performed to rule out malignancy.

5. Infection Considerations: While your symptoms and lab results suggest a possible viral infection, it’s essential to consider other infections that could cause similar symptoms, such as bacterial infections or even other viral illnesses. Your healthcare provider may consider these possibilities based on your clinical history and examination findings.

6. Monitoring: Since your doctor has advised monitoring the lymph nodes, it’s crucial to keep track of any changes in size, consistency, or associated symptoms (like fever, night sweats, or weight loss). Documenting these changes can provide valuable information for your healthcare provider.

In conclusion, while elevated mono levels and swollen lymph nodes can be concerning, they are often indicative of a benign process, especially if there are no alarming symptoms. However, ongoing monitoring and communication with your healthcare provider are essential to ensure that any potential issues are addressed promptly. If you have further concerns or if your symptoms worsen, do not hesitate to seek medical attention.

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