Should I Continue My Pregnancy After Taking Immunomodulatory Drugs? - Obstetrics and Gynecology

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Took Category X medications before pregnancy?


Hello Doctor, my last menstrual period was on January 18, 2023.
Normally, I would expect my next period around February 20, but it was delayed by about 2-3 days, so I took a pregnancy test and got two lines.
On March 1, I went to the obstetrics and gynecology department for an ultrasound, and an embryo was detected in the uterus, approximately 4 weeks along.
I have a slight immune system disorder, so I have been taking immunomodulatory medication, one of which is "Zhi Shan Tablet 2.5 mg," which I was supposed to take twice a week, three tablets each time.
Since I often forget to take it, I stopped taking this medication after a while.
To my recollection, I stopped taking it for over a month (I believe I stopped after around December 20).
However, I found online that after discontinuing this medication, it is recommended to wait for at least one complete ovulation cycle, which means going through two menstrual periods.
I would like to ask the doctor whether I should continue with the pregnancy or consider termination.
Thank you, Doctor!

zona, 20~29 year old female. Ask Date: 2023/03/03

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, since you stopped the medication before becoming pregnant, it should not have any impact.
Wishing you good health.

Reply Date: 2023/03/03

More Info


When considering whether to continue a pregnancy after taking immunomodulatory drugs, it is essential to weigh the potential risks and benefits carefully. In your case, you mentioned taking "治善錠" (likely referring to a specific immunomodulatory medication) and that you have not taken it for over a month. You also noted that you are approximately four weeks pregnant, which is a critical time for fetal development.

Firstly, it is important to understand the nature of the drug you were taking. Immunomodulatory drugs can vary widely in their effects and potential risks during pregnancy. Some medications may have teratogenic effects (causing malformations in the developing fetus), while others may not pose significant risks. The specific drug you mentioned should be evaluated based on its classification and known effects during pregnancy.

The general recommendation for women who are pregnant or planning to become pregnant is to consult with their healthcare provider about any medications they are taking. This is particularly crucial for immunomodulatory drugs, as they can affect the immune system and may have implications for both maternal and fetal health.
In your case, since you have not taken the medication for over a month, it is likely that the drug is no longer in your system. However, the concern about needing to wait for a complete ovulation cycle before trying to conceive is valid. This recommendation is often made to ensure that any potential effects of the medication are fully cleared from your body before pregnancy.
Given that you are already pregnant, the focus should now shift to monitoring the pregnancy and ensuring that both you and your baby remain healthy. Here are some key points to consider:
1. Consult Your Healthcare Provider: It is crucial to have an open and honest discussion with your obstetrician or healthcare provider about your medication history and current pregnancy. They can provide personalized advice based on your specific situation and the medication you were taking.

2. Monitoring the Pregnancy: Regular prenatal check-ups are essential to monitor the health of both you and your developing fetus. Your healthcare provider may recommend additional ultrasounds or tests to ensure that the pregnancy is progressing normally.

3. Assessing Risks: While some immunomodulatory drugs can pose risks during pregnancy, many women have successful pregnancies while managing their health conditions. Your healthcare provider can help assess the risks based on the specific medication and your health history.

4. Emotional Support: Pregnancy can be a time of heightened anxiety, especially when there are concerns about medication use. Seeking support from friends, family, or a mental health professional can be beneficial.

5. Healthy Lifestyle Choices: Focus on maintaining a healthy lifestyle during your pregnancy. This includes a balanced diet, regular prenatal vitamins (especially folic acid), staying hydrated, and avoiding harmful substances.

In conclusion, while it is understandable to have concerns about continuing your pregnancy after taking immunomodulatory drugs, the best course of action is to consult with your healthcare provider. They can provide guidance tailored to your specific circumstances and help you navigate this important time in your life. Remember, many women with similar concerns have healthy pregnancies and babies, and with the right support and care, you can too.

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