Concerns About Weight Gain and Long-Term Effects of Schizophrenia Medications - Psychiatry

Share to:

Schizophrenia


Hello, Doctor: I have been taking medication for schizophrenia for four months, and my weight has been increasing.
Will long-term use of these medications make me overweight? Are there any long-term side effects, such as diabetes or cancer? Is it safe to take these medications long-term? Should I stop taking them due to weight gain? In which year was this condition discovered? Are there people who have taken these medications for decades and remain healthy? Why does my primary physician say that no one has ever fully recovered from this condition? What is the truth? Should I consult multiple specialists? - Concerned individual.

Chen, 20~29 year old female. Ask Date: 2003/11/23

Dr. Chen Guangpeng reply Psychiatry


Dear Patient,
I have received your email again and am gradually understanding your characteristics—excessive worry, confusion, and lack of confidence.
In a serendipitous moment while trying to read the insights and experiences of my predecessors, I unexpectedly discovered that despite your efforts to seek medical help, you still feel lost.
I deeply believe that establishing a more solid therapeutic relationship is crucial for you.

The pattern of seeking medical attention you exhibit suggests a possibility—that your condition has not received adequate treatment.
This may be a cause or an effect: the lack of sufficient treatment makes you prone to suspicion and contributes to your current state of seeking help.
Such distrust in your primary physician hinders your ability to fully cooperate with the treatment plan.

Improving these issues relies on your willingness to give both your physician and yourself a chance to sit down and communicate openly, providing enough trust to develop a consensus on a treatment plan that is most beneficial for you.
Every psychiatrist, aside from extreme cases, possesses a certain level of professional competence.
Without sufficient trust and timing, even if you consult renowned specialists, it will only lead to superficial encounters, repeatedly starting another unsuccessful journey without reaching a fruitful outcome, deepening your frustrations.
So, please do not hesitate any longer, and do not continue to wander.
Without deep roots, it is impossible to thrive and bear fruit.
I hope these responses can provide you with more effective assistance, rather than merely addressing minor issues while neglecting the overarching theme.

Reply Date: 2003/11/23

More Info


When it comes to the management of schizophrenia and the medications used to treat it, concerns about weight gain and long-term health effects are quite common among patients. It’s important to address these concerns with a comprehensive understanding of the medications involved, their potential side effects, and the overall management of your condition.

First, many antipsychotic medications, particularly the atypical ones, are associated with weight gain. This is due to several factors, including changes in metabolism, increased appetite, and alterations in how the body processes glucose and fat. Medications such as Olanzapine and Clozapine are known for their higher propensity to cause weight gain compared to others like Aripiprazole or Lurasidone, which are considered to have a more favorable metabolic profile. If you are experiencing significant weight gain, it is crucial to discuss this with your prescribing physician. They may consider adjusting your medication or dosage, or potentially switching to a different medication that has a lower risk of weight gain.

Regarding your concerns about long-term effects, chronic use of antipsychotic medications can indeed lead to metabolic syndrome, which includes obesity, hypertension, dyslipidemia, and insulin resistance. This syndrome significantly increases the risk of developing type 2 diabetes and cardiovascular diseases. Regular monitoring of weight, blood glucose levels, and lipid profiles is essential for anyone on these medications. Your doctor should schedule routine blood tests to monitor these parameters, especially if you notice weight changes.

As for the fear of developing severe conditions like cancer, while some studies have suggested a potential link between long-term antipsychotic use and certain health risks, the evidence is not definitive. The benefits of managing schizophrenia effectively often outweigh the potential risks associated with medication. It is essential to maintain open communication with your healthcare provider about any concerns you have regarding your treatment and its side effects.

You mentioned the possibility of discontinuing your medication due to weight gain. It is crucial to avoid making any changes to your medication regimen without consulting your doctor. Abruptly stopping antipsychotic medications can lead to withdrawal symptoms and a potential relapse of your schizophrenia. Instead, work with your doctor to find a solution that balances effective symptom management with your concerns about weight and overall health.

Regarding the historical context of schizophrenia, it has been recognized for centuries, with significant advancements in understanding and treatment occurring over the last century. While your doctor may have mentioned that no one "cures" schizophrenia, many individuals can manage their symptoms effectively with the right treatment plan, which may include medication, therapy, and lifestyle changes.

If you feel that your current treatment plan is not addressing your concerns adequately, seeking a second opinion from another psychiatrist can be a reasonable step. However, ensure that you have a clear understanding of your treatment goals and the rationale behind your current medication regimen before making any changes.

In summary, weight gain is a common concern with antipsychotic medications, and it is essential to address this with your healthcare provider. Regular monitoring and open communication about your treatment plan can help mitigate risks and improve your overall well-being. Remember, managing schizophrenia is a long-term commitment, and with the right support, many individuals lead fulfilling lives despite their diagnosis.

Similar Q&A

Do Psychiatric Medications Cause Weight Gain? Understanding Your Concerns

Hello, doctor. I am currently seeing a psychiatrist and taking Risperidone, Deansox, Rifampicin, and extended-release Quetiapine. I would like to ask if taking these medications could lead to weight gain. I am concerned because continuous weight gain affects my mood negatively.


Dr. Li Zhengfeng reply Psychiatry
Hello: Risperidone can indeed stimulate appetite and lead to weight gain. If you are experiencing this issue, you may want to discuss it with your treating physician.

[Read More] Do Psychiatric Medications Cause Weight Gain? Understanding Your Concerns


Weight Gain from Medication: Struggling to Lose After Switching Drugs

Due to schizophrenia, I have been on medication for a year now. Initially, I gained 25 kilograms because of the side effects. In the middle of my treatment, I asked my doctor to switch to a medication that wouldn't cause weight gain, but my weight has not been able to decrea...


Dr. Cai Zongzhang reply Neurology
Hello, Youyou: The symptoms mentioned above are not caused by a neurological disorder. It is recommended that you discuss medication with the psychiatrist who is treating you for schizophrenia.

[Read More] Weight Gain from Medication: Struggling to Lose After Switching Drugs


Understanding Abilify: Side Effects, Weight Gain, and Its Use in Schizophrenia

Abilify (aripiprazole) can have several side effects. Common side effects include weight gain and drowsiness. It may also exhibit side effects similar to older antipsychotic medications, such as extrapyramidal symptoms (EPS), which can include tremors, rigidity, and restlessness....


Dr. Tang Xinbei reply Psychiatry
Dear friend: You inquired about Abilify, which is an antipsychotic medication that was launched in Taiwan earlier this year and has also been available in other countries for only the past year or two, resulting in limited clinical experience. Regarding the side effects of this m...

[Read More] Understanding Abilify: Side Effects, Weight Gain, and Its Use in Schizophrenia


Managing Weight Gain on Antipsychotics: Switching Medications Safely

Hello Dr. Tang: I have been taking Risperidone for a year since my onset of illness in July 2023. I originally took one and a half pills a day, but I have reduced it to one pill every two days. However, I have gained twenty kilograms. Now that my condition has stabilized, I would...


Dr. Tang Jiahong reply Psychiatry
Hello: According to the prescribing information for lurasidone, the average weight gain in the LATUDA treatment group was 0.43 kg, while the average weight loss in the placebo group was 0.02 kg. In short-term placebo-controlled trials for schizophrenia in adults, the incidence of...

[Read More] Managing Weight Gain on Antipsychotics: Switching Medications Safely


Related FAQ

Schizophrenia

(Psychiatry)

Anorexia Nervosa

(Psychiatry)

Side Effects Of Medication

(Psychiatry)

Binge Eating

(Psychiatry)

Medications

(Psychiatry)

Worry

(Psychiatry)

Delusion

(Psychiatry)

Autism

(Psychiatry)

Ptsd

(Psychiatry)

Obsessive Thoughts

(Psychiatry)