Drug Side Effects: Hyperthyroidism and Medication Risks - Family Medicine

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Drug side effects: Hyperthyroidism


Hello, since I have been receiving treatment at the same hospital, my doctor previously prescribed "Mometasone nasal spray" for my nasal allergies to be used once daily.
However, after I got home and took the medication, I noticed on the medication bag that patients with hyperthyroidism should confirm with their doctor.
Currently, I am taking "Levocetirizine" daily and have a history of hyperthyroidism (I am no longer on medication and only return to the hospital for follow-up every six months).
Will taking this medication cause any problems (side effects)?

Josey, 30~39 year old female. Ask Date: 2023/03/07

Dr. Lin Zhebin reply Family Medicine


Hello: The main ingredients in the sustained-release tablet of Morbica are Loratadine (an antihistamine) and Pseudoephedrine (a decongestant).
The component Pseudoephedrine can cause side effects similar to sympathetic nervous system stimulation, such as tremors, palpitations, hypertension, sweating, excitability, and insomnia.
These side effects are similar to the clinical symptoms of hyperthyroidism and can exacerbate the effects and discomfort caused by hyperthyroidism.
Therefore, patients with hyperthyroidism are generally not suitable for this medication.
It is recommended that you monitor for the aforementioned side effects after taking the medication.
If they occur, it is advisable to discontinue the medication and consult your physician to discuss alternative treatments for nasal allergies.

Reply Date: 2023/03/07

More Info


When it comes to managing hyperthyroidism and the potential risks associated with medication, it is crucial to understand how certain drugs can interact with your condition and the possible side effects they may cause. Hyperthyroidism, characterized by an overactive thyroid gland, can lead to various symptoms such as weight loss, increased heart rate, anxiety, and heat intolerance. The management of this condition often involves medications that can either inhibit thyroid hormone production or block the effects of these hormones on the body.

In your case, you mentioned taking "Moxifloxacin" (the name you provided seems to be a typo, as "莫鼻卡" does not correspond to a known medication) and "Doxepin" (异位宁), which is an antihistamine and antidepressant. While Doxepin is primarily used for treating allergies and depression, it can also have sedative effects. It is important to note that certain medications, including antihistamines, can potentially exacerbate symptoms of hyperthyroidism or interact with other medications you may be taking.

One of the primary concerns with antihistamines in patients with a history of hyperthyroidism is their sedative properties. Doxepin can cause drowsiness, dizziness, and confusion, which may be particularly problematic for individuals who are already experiencing symptoms related to hyperthyroidism. Additionally, antihistamines can sometimes lead to increased heart rate or palpitations, which can be concerning for someone with a history of thyroid issues.

Moreover, if you are taking other medications for your thyroid condition or any other health issues, it is essential to consider potential drug interactions. For instance, certain medications used to manage hyperthyroidism, such as methimazole or propylthiouracil, can interact with other drugs, leading to increased side effects or reduced effectiveness of treatment.

In terms of side effects, Doxepin may cause dry mouth, constipation, urinary retention, and blurred vision, which are common anticholinergic effects. These side effects can be particularly bothersome and may require adjustments in your medication regimen. Additionally, if you experience any signs of an allergic reaction, such as rash, itching, or difficulty breathing, it is crucial to seek medical attention immediately.

Given your history of hyperthyroidism and the medications you are currently taking, it is advisable to consult your healthcare provider before continuing with Doxepin or any other new medication. They can provide personalized recommendations based on your medical history and current health status. Regular monitoring of your thyroid function is also essential, especially if you are taking medications that may influence your thyroid hormone levels or overall metabolic state.

In summary, while Doxepin can be effective for managing allergy symptoms and providing sedation, it is essential to be cautious due to its potential side effects and interactions with your history of hyperthyroidism. Always communicate openly with your healthcare provider about any concerns or side effects you experience while on medication, and ensure that all your healthcare providers are aware of your complete medication list to avoid any adverse interactions.

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