Can I Get the Fifth COVID Vaccine After Lymph Node Swelling? - Influenza

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COVID-19 vaccine


After receiving the fourth dose of the BA.1/2 COVID-19 vaccine, I experienced swelling and pain in my armpit for about a week before returning to normal.
Upon researching, I found that the side effect of the vaccine could be lymphadenopathy.
I would like to ask the doctor if I can proceed with the fifth dose of the BA.4/5 vaccine?

A, 40~49 year old female. Ask Date: 2023/03/08

Dr. Yang Zongyan reply Influenza


After receiving the fourth dose of the BA.1/2 COVID-19 vaccine, I experienced swelling and pain in the armpit of the vaccinated arm, which returned to normal after about a week.
Upon checking, I found that the side effect of the vaccine could be lymphadenopathy.
I would like to ask the doctor if I can proceed with the fifth dose of the BA.4/5 vaccine.
-----ANS: If you experienced lymphadenopathy and pain after vaccination, it could be a side effect of the vaccine.
However, if the symptoms have resolved, it is advisable to seek medical attention if they persist.
If you have fully recovered, you can continue with the fifth dose of the BA.4/5 vaccine according to the recommended schedule provided by the health authorities.

Reply Date: 2023/03/08

More Info


After experiencing lymph node swelling following your fourth dose of the COVID-19 vaccine, it is understandable to have concerns about receiving the fifth dose. Lymphadenopathy, or swelling of the lymph nodes, is a known side effect of many vaccines, including COVID-19 vaccines. This reaction typically occurs as the immune system responds to the vaccine, which is designed to stimulate an immune response against the virus.

In your case, since the swelling and pain in your armpit resolved within a week, it suggests that your body responded normally to the vaccine. The Centers for Disease Control and Prevention (CDC) and other health authorities have indicated that mild to moderate side effects, including lymph node swelling, are common and usually resolve without intervention.
Regarding your question about receiving the fifth dose of the BA.4/5 vaccine, it is generally considered safe to proceed with vaccination after experiencing mild side effects from a previous dose. However, it is essential to consult with your healthcare provider before making a decision. They can assess your overall health, review your vaccination history, and provide personalized advice based on your medical background.

Here are some additional considerations:
1. Timing of Vaccination: If you are feeling well and have recovered from any side effects, you can typically proceed with the next dose. However, if you are still experiencing symptoms or have concerns, it may be prudent to wait until you feel completely recovered.

2. Monitoring for Side Effects: After receiving the fifth dose, continue to monitor for any side effects. While lymph node swelling can occur again, it is usually temporary. If you experience severe or prolonged symptoms, contact your healthcare provider.

3. Underlying Health Conditions: If you have any underlying health conditions or are taking medications that affect your immune system, discuss these with your healthcare provider. They may have specific recommendations based on your health status.

4. Importance of Vaccination: Vaccination remains a critical tool in preventing severe illness from COVID-19. The benefits of receiving the vaccine, especially with the emergence of new variants, often outweigh the risks of side effects.
5. Consultation with Specialists: If you have ongoing concerns about lymphadenopathy or any other symptoms, consider consulting a specialist, such as an immunologist or an infectious disease expert. They can provide further insights into your specific situation.

In summary, it is generally safe to receive the fifth COVID-19 vaccine dose after experiencing mild lymph node swelling from the previous dose, especially if the symptoms have resolved. However, always consult with your healthcare provider for tailored advice and to ensure that you are making the best decision for your health. Vaccination is crucial in protecting yourself and others from COVID-19, and staying informed about your health is key to making the right choices.

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