Combining Vaginal Suppositories and Oral Medications for Yeast Infections - Obstetrics and Gynecology

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Vaginal suppositories + oral medication


Hello, doctor.
Recently, I was treated for a vaginal yeast infection, and the clinic provided me with a suppository and prescribed a three-day course of oral medication (nystatin).
Since I will be starting my period in about three days, the doctor also gave me three suppositories.
Should I use the oral medication and the suppositories together for three days, or should I finish the suppositories first and then take the oral medication when my period starts? I apologize for forgetting to ask during the appointment.
Thank you for your help.

Niming, 20~29 year old female. Ask Date: 2023/03/10

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, oral medications and vaginal suppositories can be used together.
If you have your period, do not use the suppository; wait until it is finished before using it again.
Wishing you good health.

Reply Date: 2023/03/10

More Info


When it comes to treating a vaginal yeast infection, the combination of vaginal suppositories and oral medications can be an effective approach. In your case, you have been prescribed a vaginal suppository and an oral medication (Nystatin) to address the infection. It’s important to understand how to properly use these medications to maximize their effectiveness and ensure a smooth recovery.

Typically, the treatment regimen for a yeast infection can involve both local (vaginal) and systemic (oral) medications. The vaginal suppository is designed to deliver medication directly to the site of infection, which can provide rapid relief from symptoms such as itching, burning, and discharge. On the other hand, oral medications like Nystatin work systemically to help eliminate the yeast infection from the body.

In your situation, it is generally recommended to use the vaginal suppository as directed, which is usually for a specific number of days (in your case, three days). You should complete the full course of the suppository treatment before starting the oral medication. This is because the vaginal suppository will work locally to address the infection, and it’s best to allow it to do its job without interference from the oral medication initially.

Once you have completed the vaginal suppository treatment, you can then start taking the oral Nystatin. This approach allows for a more targeted treatment strategy, where the suppository can help alleviate symptoms quickly, and the oral medication can provide additional support to eliminate the infection more thoroughly.

Regarding your concern about the timing of your menstrual cycle, it’s important to note that having your period should not significantly affect the efficacy of either the vaginal suppository or the oral medication. However, if you are using the vaginal suppository during your menstrual period, you may experience some leakage, which is normal. It’s advisable to maintain good hygiene during this time and to continue with the oral medication as prescribed.

If you have any doubts or if symptoms persist after completing the treatment, it’s crucial to follow up with your healthcare provider. They may want to reassess your condition or consider alternative treatments if necessary. Additionally, if you experience any unusual side effects or worsening symptoms, do not hesitate to reach out for medical advice.

In summary, for your treatment plan, you should use the vaginal suppository for the full three days as directed, and then start the oral Nystatin after completing the suppository treatment. This method will help ensure that you effectively address the yeast infection while managing any potential interactions between the two forms of medication. Always remember to consult your healthcare provider for personalized advice and guidance tailored to your specific situation.

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