Mitral Valve Prolapse: Symptoms, Treatments, and Surgical Options - Cardiology

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Valvular insufficiency


Hello Doctor, my mother is nearly 60 years old.
Recently, she experienced heart discomfort and was diagnosed with moderate mitral valve prolapse (regurgitation + blood flow reversal) and mild tricuspid valve prolapse, with slight cardiac enlargement.
The first physician prescribed Diltiazem 80 mg, half a tablet, but she has been experiencing continuous chest pain and back pain.
The second physician prescribed Clopidogrel 50 mg, half a tablet daily, and Amlodipine 25 mg, half a tablet daily, but she is experiencing arm pain, dizziness, and a feeling of weakness.
Below are the examination results:
Doppler Color Flow Echocardiography:
Result:
TAPE NO.
< GE E9 > BEGINS < > ENDS < > WT: < > KG
TAPE NO.
< > BEGINS < > ENDS < > BP:< >/< > mmHg
COMMENTS:
LA (4.2 CM) CHAMBER DILATATION
LV (5.2, 3.1 CM) CHAMBER SIZE
MILD AR & PR
PROLAPSE OF ANTERIOR MITRAL LEAFLET WITH MODERATE MR
MODERATE TR WITH PEAK/MEAN SYSTOLIC PG -- 39/25 mmHg
SUGGEST PULMONARY HYPERTENSION
NORMAL LV SYSTOLIC WALL MOTION.

THE LV EJECTION FRACTION IS 58%
MV E/A RATIO > 1
MV E/E’ SEPTAL— 10.8
MV E/E’ LATERAL — 6.5
Myocardial Perfusion Gated SPECT Study:
Result:
Finding: A myocardial perfusion gated SPECT study using Tc-99m MIBI obtained in both persantin-stress and rest status (one-day protocol):
Moderately decreased myocardial perfusion at the following areas:
-- the apex and the apical lateral wall, the apical to mid anterior wall under persantin-stress status with marked recovery on rest status.

-- the mid to basal inferolateral wall under persantin-stress status with no apparent change on rest status.

-- the mid anteroseptal wall under persantin-stress status, which showed more pronounced on rest status (reverse redistribution).

Normal wall motion of the left ventricle.

Ejection Fraction (EF) of left ventricle:
-- Under Stress = 60%
-- After Resting = 61%.

Impression:
-- The moderately decreased myocardial perfusion at the apex and the apical lateral wall, the apical to mid anterior wall, and the reverse redistribution at the mid anteroseptal wall may be due to coronary artery disease (ischemia with or without infarction).
Further evaluation or close follow-up is recommended.

-- The moderately decreased myocardial perfusion at the mid to basal inferolateral wall may be due to mild coronary artery disease or have no clinical significance (attenuation effect or motion artifact by diaphragm).
Suggest medical treatment first with close follow-up.

-- Reference for the interpretation of reverse redistribution: In patients without infarction and high pretest likelihood of coronary artery disease, reverse redistribution is evaluated as ischemia, whereas in subjects with low pretest likelihood, this finding has no diagnostic value.
In a patient with a previous myocardial infarction, reverse redistribution at the infarct site is evaluated as a sign of viability.
I would like to ask the following questions:
1.
Are the recent symptoms of chest pain, arm pain, and back pain side effects of the medication or potential issues related to her underlying condition?
2.
Which medication would you recommend, or should we consider changing her medication?
3.
The doctor mentioned that surgical valve repair could be an option, but it may require out-of-pocket expenses, potentially up to a million.
Based on the current examination results, would you recommend surgery or continuing with medication and observation?
4.
If surgery is recommended, which approach would you suggest?
Thank you for your response, Doctor.

Yu Yu, 60~69 year old female. Ask Date: 2023/03/23

Dr. Wu Xueming reply Cardiology


Moderate mitral valve regurgitation does not require surgery; medication management and regular follow-up are sufficient.

Reply Date: 2023/03/23

More Info


Mitral Valve Prolapse (MVP) is a condition where the mitral valve does not close properly, leading to potential complications such as mitral regurgitation (MR) and, in some cases, heart enlargement. Given your mother's recent diagnosis of moderate mitral valve prolapse with associated regurgitation and mild tricuspid regurgitation, it is essential to understand the implications of her condition, the symptoms she is experiencing, and the treatment options available.


Symptoms of Mitral Valve Prolapse
Patients with MVP may experience a variety of symptoms, including:
- Chest pain or discomfort
- Palpitations or irregular heartbeats
- Fatigue or weakness
- Shortness of breath, especially during exertion
- Dizziness or lightheadedness
In your mother's case, the chest pain, back pain, and arm pain could be attributed to a combination of factors, including the side effects of the medications prescribed and the underlying condition itself. It is crucial to differentiate whether these symptoms are due to the medications (such as side effects from beta-blockers or other heart medications) or are manifestations of the MVP and its complications.


Treatment Options
1. Medications: The initial approach to managing MVP often involves medications to alleviate symptoms. Beta-blockers, such as the ones prescribed (e.g., Atenolol), can help manage palpitations and chest pain. If your mother is experiencing significant side effects, it may be worth discussing alternative medications with her healthcare provider. Other options may include anti-anxiety medications or adjusting the dosage of current medications.

2. Monitoring: Regular follow-ups with echocardiograms are essential to monitor the progression of the valve disease and the heart's function. If the left atrium is dilated and there is evidence of pulmonary hypertension, this may indicate that the condition is worsening and requires closer observation.

3. Surgical Options: Surgical intervention may be considered if the mitral regurgitation is severe and symptomatic, or if there is evidence of heart failure or significant left ventricular dysfunction. Surgical options include:
- Mitral Valve Repair: This is often the preferred approach as it preserves the valve's function and structure. It can involve techniques such as resection of the redundant valve tissue or chordal replacement.

- Mitral Valve Replacement: This may be necessary if the valve is too damaged to repair. Replacement can be done with mechanical or biological valves.


Recommendations
1. Symptom Management: If the current medications are causing significant side effects, it is advisable to consult with her cardiologist to explore alternative treatments or adjust dosages.

2. Surgical Evaluation: Given the moderate MR and the symptoms your mother is experiencing, a surgical evaluation may be warranted. The decision to proceed with surgery should be based on a thorough assessment of her symptoms, echocardiographic findings, and overall health status. If surgery is recommended, it is essential to discuss the types of procedures available, the risks involved, and the potential costs.

3. Lifestyle Modifications: Encourage your mother to maintain a heart-healthy lifestyle, including a balanced diet, regular exercise (as tolerated), and stress management techniques. These can help improve her overall cardiovascular health and may alleviate some symptoms.

4. Follow-Up Care: Regular follow-ups with her cardiologist are crucial to monitor her condition and adjust treatment as necessary. If symptoms worsen or new symptoms arise, prompt medical attention is essential.

In conclusion, while MVP can be a manageable condition, it requires careful monitoring and appropriate treatment. Open communication with her healthcare team will ensure that your mother receives the best possible care tailored to her specific needs.

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