Can Long-Term SSRI Use Cause Harm to Normal Individuals? - Psychiatry

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Doctor, I would like to ask: Q: If I am a normal person, is it possible that taking SSRIs for a long time or in excess could lead to depression or cause harm when not taking them? When I was 17 or 18 years old, I felt that I was easily anxious and took two tablets of an antidepressant for a while.
Eventually, I reduced the dosage to a quarter of a tablet, but I still felt significant effects from the medication.
At that time, I was younger and thought I needed to take the medication.
Now that I am 20, I realize that my anxiety is actually within a normal range, and I probably wouldn’t choose to take medication if I could go back.
However, I am hesitant to ask my original doctor if it was appropriate to prescribe medication to me at that time.
Now it feels too late to inquire, but I still wonder if it has caused any damage to my brain.
I don’t have a specific purpose for asking; I just really want to know the answer.
I have consulted other doctors, but their answers vary.
Some believe that it’s okay to take low doses of medication for feeling down, while others say I don’t need medication and that taking it could actually be harmful (which is quite confusing).

A, 20~29 year old female. Ask Date: 2023/03/31

Dr. Qiu Junda reply Psychiatry


Hello.
SSRIs are antidepressants that should be used long-term by patients with depression, although the dosage can be adjusted.
If a patient stops taking them and experiences a relapse of depression, it further proves that one should not discontinue the medication without guidance.
Additionally, SSRIs are metabolized in the body and will not cause the harm to the brain that you may be concerned about, nor will taking the medication unnecessarily lead to any adverse effects.

Reply Date: 2023/03/31

More Info


The question of whether long-term use of selective serotonin reuptake inhibitors (SSRIs) can cause harm to individuals who are otherwise considered normal is a complex one. SSRIs are primarily prescribed for the treatment of depression and anxiety disorders, and they work by increasing the levels of serotonin in the brain, which can help improve mood and reduce anxiety. However, concerns about their long-term effects, especially in individuals who may not have a clinical diagnosis of depression or anxiety, are valid and warrant careful consideration.

First, it is important to acknowledge that SSRIs can have side effects, and their impact can vary significantly from person to person. Some individuals may experience side effects such as weight gain, sexual dysfunction, insomnia, or emotional blunting, which can affect their quality of life. In some cases, individuals may feel less emotionally responsive or more apathetic while on SSRIs, which can lead to concerns about whether these medications are appropriate for them, especially if they do not have a severe mental health condition.

Regarding the concern about SSRIs potentially causing harm to individuals who are not clinically depressed or anxious, research suggests that long-term use of SSRIs in such populations may not be necessary and could lead to dependency on the medication. While SSRIs are generally considered safe, there is a risk of developing tolerance, where the effectiveness of the medication diminishes over time, leading individuals to require higher doses to achieve the same effect. This can create a cycle of increasing dosage and potential side effects.

Moreover, there is ongoing debate among healthcare professionals about the appropriateness of prescribing SSRIs to individuals with mild anxiety or stress. Some practitioners advocate for a more conservative approach, suggesting that therapy or lifestyle changes, such as exercise, mindfulness, and stress management techniques, may be more beneficial for individuals who do not meet the criteria for a major depressive disorder or generalized anxiety disorder.

It is also essential to consider the potential for withdrawal symptoms when discontinuing SSRIs after long-term use. Some individuals may experience withdrawal symptoms, such as dizziness, irritability, or mood swings, which can be distressing and may lead them to continue taking the medication even if they no longer feel it is necessary.

In your case, it appears that you have been on SSRIs since a young age and are now questioning their necessity and impact on your mental health. It is crucial to have an open and honest discussion with your healthcare provider about your concerns. They can help assess your current mental health status and determine whether continuing the medication is appropriate or if a gradual tapering off might be beneficial.
Ultimately, the decision to continue or discontinue SSRIs should be made collaboratively between you and your healthcare provider, taking into account your individual circumstances, mental health history, and any potential risks associated with long-term use. If you feel that your anxiety is within a normal range and manageable without medication, it may be worth exploring alternative treatments or therapies that can support your mental well-being without the need for SSRIs.
In conclusion, while SSRIs can be effective for treating depression and anxiety, their long-term use in individuals without a clinical diagnosis should be approached with caution. Regular evaluations and discussions with a healthcare provider can help ensure that any treatment plan is tailored to your specific needs and circumstances, minimizing the risk of unnecessary harm.

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