Managing Syphilis Treatment: Can Xyzal Help with Itching? - Urology

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Medications used in the treatment of syphilis?


Hello, doctor! I have received three doses of penicillin and am taking Doxycycline 100 mg capsules twice daily for 28 days.
I am experiencing mild itchy rashes on my face as a side effect.
Can I use Xyzal (Levocetirizine) 5 mg to relieve the itching discomfort? Thank you!

Dong, 40~49 year old female. Ask Date: 2023/04/05

Dr. Fu Shizhang reply Urology


Mild drug allergies can be treated with antihistamines.
Online consultations cannot replace in-person evaluations and physical examinations by a physician.
It is still recommended to seek medical attention at a healthcare facility when experiencing illness.

Reply Date: 2023/04/05

More Info


When managing syphilis treatment, it is crucial to follow the prescribed antibiotic regimen, which in your case includes benzathine penicillin and doxycycline. These medications are effective in treating syphilis, but they can sometimes lead to side effects, including skin reactions such as itching or rashes.
Xyzal (levocetirizine) is an antihistamine that is commonly used to relieve allergy symptoms, including itching and hives. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Given that you are experiencing itching as a side effect of your current treatment, using Xyzal can be a reasonable option to alleviate this discomfort. However, it is essential to consult with your healthcare provider before adding any new medication to your treatment plan, especially since you are currently undergoing treatment for syphilis.

In general, antihistamines like Xyzal can be safely used alongside antibiotics, but individual responses can vary. Your healthcare provider will consider your overall health, the severity of your symptoms, and any potential interactions with your current medications before making a recommendation. If the itching is mild and manageable, they may suggest monitoring it without additional medication. However, if the itching is bothersome, they may approve the use of Xyzal or suggest alternative treatments.

It is also important to note that while antihistamines can help with itching, they do not treat the underlying cause of the rash or skin reaction. If the rash worsens or if you experience additional symptoms, such as swelling, difficulty breathing, or other signs of an allergic reaction, you should seek medical attention immediately.

In summary, while Xyzal can help manage itching associated with your treatment for syphilis, it is essential to discuss this with your healthcare provider to ensure it is appropriate for your specific situation. They can provide guidance on the best course of action to manage your symptoms while continuing effective treatment for syphilis.

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