Can You Get Monkeypox Vaccine While on HIV PEP Treatment?

Q: Can You Get Monkeypox Vaccine While on HIV PEP Treatment?

Hello： Current data indicates that there are no significant drug interactions between post-exposure prophylaxis (PEP) for HIV and the monkeypox vaccine, suggesting that PEP's efficacy and the effectiveness of the monkeypox vaccine should not be affected.

Post-exposure prophylaxis for HIV and monkeypox vaccination?

Hello doctor, I am currently taking HIV post-exposure prophylaxis (PEP) and I am on the fourth day of the treatment.
I have recently scheduled an appointment for the monkeypox vaccine and would like to know if it is safe to receive the vaccine while on this medication.
Will it affect the efficacy of the medication or the vaccine? Thank you!

S, 20~29 year old female. Ask Date: 2023/04/15

Dr. Lin Zhebin reply Family Medicine

Hello: Current data indicates that there are no significant drug interactions between post-exposure prophylaxis (PEP) for HIV and the monkeypox vaccine, suggesting that PEP's efficacy and the effectiveness of the monkeypox vaccine should not be affected.

Reply Date: 2023/04/15

More Info

Yes, you can receive the monkeypox vaccine while on HIV post-exposure prophylaxis (PEP) treatment. Current medical literature indicates that there are no significant drug interactions between the medications used in PEP and the monkeypox vaccine. Therefore, taking PEP should not affect the efficacy of the vaccine, nor should the vaccine interfere with the effectiveness of the PEP treatment.

To elaborate further, PEP is a treatment regimen that is initiated after potential exposure to HIV, typically involving antiretroviral medications taken for a duration of 28 days. The goal of PEP is to prevent the establishment of HIV infection in the body. It is crucial to start PEP as soon as possible after exposure, ideally within 72 hours, and to adhere strictly to the medication schedule for maximum effectiveness.

On the other hand, the monkeypox vaccine is designed to provide immunity against the monkeypox virus, which is a viral infection related to smallpox. The vaccine is particularly recommended for individuals at high risk of exposure, including those who may have had close contact with someone infected with monkeypox. The vaccine can significantly reduce the risk of infection and, if administered after exposure, can also lessen the severity of the disease.

In your case, since you are currently on PEP and have an appointment for the monkeypox vaccine, it is advisable to proceed with the vaccination. The timing of the vaccination is also important; for optimal protection, it is recommended to receive the monkeypox vaccine within 14 days of potential exposure to the virus. However, even if you are beyond this window, vaccination can still provide benefits.

It is also worth noting that while the monkeypox vaccine can reduce the likelihood of infection and the severity of symptoms, it does not provide 100% protection. Therefore, it is essential to continue practicing safe behaviors, such as avoiding close contact with individuals who are symptomatic or confirmed to have monkeypox, regardless of vaccination status.

In summary, receiving the monkeypox vaccine while on HIV PEP is safe and should not compromise either treatment's effectiveness. It is always a good practice to discuss any concerns with your healthcare provider, who can provide personalized advice based on your health status and circumstances.

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