Can MRI Detect Cancer Cells in Unremoved Prostate? Expert Insights - Urology

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Continuation of Q&A #195491?


I would like to ask the doctor about the Q&A #195491.
Is it possible to determine the presence of cancer cells in the unremoved prostate using MRI with PET scanning? My father has undergone this examination, and the results showed no issues.
After his prostate laser surgery, he felt he had mostly recovered after a month and a half, so he attended a friend's gathering and drank alcohol.
My father has a tendency to flush when drinking, and after receiving a heart stent, the flushing became more pronounced and lasted longer.
He has since reduced his alcohol intake, but he still occasionally drinks a little.
Before a blood test at the end of March, he had consumed alcohol, which may have led to prostate inflammation.
I would like to know if adding the free PSA ratio would provide more accurate results.

Xiao Ling, 40~49 year old female. Ask Date: 2023/04/20

Dr. Du Shixi reply Urology


Hello: MRI can be referenced, but it is generally recommended to wait for a period of time before surgery, as it may affect the interpretation even if a stent is placed.
In addition to medication, lifestyle habits should be taken into consideration.
First, identify the causes of vascular obstruction; if any are present, it is advisable to eliminate or change them.
It is essential to develop good habits, as having a stent does not guarantee that heart problems will not occur again.
Exercise caution; if possible, alcohol and smoking are absolutely not recommended.
Drinking alcohol should not affect the test values; most often, inflammation or cancer can influence the results.
Wishing you good health.

Reply Date: 2023/04/20

More Info


MRI (Magnetic Resonance Imaging) is a powerful imaging tool that can provide detailed images of the prostate and surrounding tissues. However, its effectiveness in detecting prostate cancer cells, especially in cases where the prostate has not been removed, can be variable. MRI is particularly useful for assessing the size and extent of known tumors, but it may not always detect small or early-stage cancers. This is partly due to the limitations of MRI in differentiating between cancerous and non-cancerous tissues, especially when the lesions are small or located in challenging areas, such as near the urethra.

In the case of your father, who underwent an MRI after laser surgery for prostate issues, it is possible that the imaging did not reveal any cancerous cells due to several factors. First, if the cancer was small or in a location that is difficult to visualize, it might not have been detected. Additionally, post-surgical changes, such as inflammation or scarring, can obscure the imaging results, making it harder to identify any residual cancer.

Regarding the Free PSA (Prostate-Specific Antigen) ratio, this test can indeed provide additional insights into prostate health. Total PSA levels can be elevated for various reasons, including benign prostatic hyperplasia (BPH), prostatitis (inflammation of the prostate), and prostate cancer. The Free PSA test measures the proportion of PSA that is not bound to proteins in the blood. A lower percentage of Free PSA is often associated with a higher likelihood of prostate cancer. Therefore, incorporating Free PSA testing can enhance the accuracy of prostate cancer diagnosis, especially when total PSA levels are elevated.

In your father's case, if he has experienced elevated PSA levels and has undergone imaging that did not reveal cancer, measuring Free PSA could help clarify the situation. If the Free PSA ratio indicates a higher risk of cancer, further diagnostic procedures, such as repeat biopsies or additional imaging, might be warranted.

It is also important to consider lifestyle factors, such as alcohol consumption, which can influence prostate health. Alcohol can exacerbate inflammation and may contribute to elevated PSA levels. Given your father's history of heart issues and the installation of a stent, it is wise for him to limit alcohol intake, as it can have various effects on cardiovascular health and overall well-being.

In summary, while MRI is a valuable tool for assessing prostate cancer, its ability to detect cancer cells in an unremoved prostate can be limited. The addition of Free PSA testing can provide further clarity in diagnosing prostate conditions. It is essential for your father to maintain open communication with his healthcare provider to monitor his condition and make informed decisions regarding further testing or lifestyle adjustments. Regular follow-ups and a comprehensive approach to his health will be crucial in managing his prostate health effectively.

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