Yellow Discharge After Nystatin Treatment for Vaginal Infection - Obstetrics and Gynecology

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Vaginal suppository with yellow discharge the next day?


Hello Doctor, I recently had a vaginal candidiasis infection, and on April 12, the doctor prescribed me Nystatin suppositories.
I used them for 7 days, and during this time, I noticed yellow discharge every other day.
(Additionally, I had a trichomoniasis infection last December, and after completing the treatment, the yellow-green discharge resolved.)
1.
Since the suppositories are white, I am wondering if the presence of yellow discharge indicates that the infection has not fully resolved?
2.
Could you please explain why I am experiencing yellow discharge? I am concerned that the previous trichomoniasis infection may not have been completely treated.
Thank you, Doctor.

Ms. Zeng, 20~29 year old female. Ask Date: 2023/04/20

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it is possible that there is still inflammation.
I recommend returning to the obstetrics and gynecology department for an examination.
Wishing you good health.

Reply Date: 2023/04/20

More Info


When dealing with a vaginal yeast infection, it's common for patients to have concerns about the treatment process and any unusual symptoms that may arise. In your case, you've been using Nystatin vaginal suppositories for seven days, and you've noticed a yellow discharge during this time. Let's address your concerns regarding the yellow discharge and its implications for your treatment.

Firstly, it's important to understand that Nystatin is an antifungal medication specifically used to treat yeast infections, such as those caused by Candida species. The suppository form of Nystatin is designed to deliver the medication directly to the affected area, which can help alleviate symptoms like itching, burning, and abnormal discharge.

Now, regarding the yellow discharge you are experiencing, there are a few potential explanations:
1. Normal Response to Treatment: After starting treatment for a yeast infection, it's not uncommon to notice changes in vaginal discharge. The yellow color could be a result of the body’s response to the infection and the treatment. As the yeast infection begins to resolve, the discharge may change in color and consistency. This is often a sign that the body is clearing out the infection.

2. Residual Infection: While Nystatin is effective against yeast infections, it's possible that the infection may not be fully resolved yet. If the discharge persists or worsens, it could indicate that the infection is still present or that there is another underlying issue.
3. Other Infections: Given your history of a trichomonas infection, it's understandable to be concerned about the possibility of a recurring or unresolved infection. Trichomonas can cause yellow-green discharge, and if you had a previous infection, it's essential to ensure that it has been fully treated.
4. Bacterial Vaginosis (BV): Another possibility is that the yellow discharge could be related to bacterial vaginosis, which is a different type of vaginal infection. BV can cause a change in discharge and is often characterized by a fishy odor.
In light of these possibilities, here are some recommendations:
- Monitor Your Symptoms: Keep an eye on the discharge and any other symptoms you may experience, such as itching, burning, or odor. If the discharge continues to be yellow or if you develop new symptoms, it may be time to consult your healthcare provider.

- Follow Up with Your Doctor: Given your concerns about the yellow discharge and your history of infections, it would be wise to schedule a follow-up appointment with your healthcare provider. They may want to perform a pelvic exam or conduct tests to determine if there is an ongoing infection or if the discharge is a normal part of the healing process.

- Avoid Self-Diagnosis: While it’s natural to worry about your symptoms, self-diagnosing can lead to unnecessary anxiety. Trust your healthcare provider to give you the best advice based on your specific situation.

In conclusion, while yellow discharge after starting Nystatin treatment can be a normal part of the healing process, it’s essential to remain vigilant and consult your healthcare provider if you have any concerns. They can provide the most accurate diagnosis and ensure that any underlying issues are addressed promptly. Your health and peace of mind are paramount, so don’t hesitate to reach out for professional guidance.

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