Post-Stent Weakness: Heart, Liver, or Medication Issues? - Cardiology

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Dear Dr.
Huang,
Thank you for your previous response.
My father underwent a cardiac catheterization in mid-March, which revealed that all three coronary arteries were blocked.
The cardiologist referred him to the hepatobiliary and cardiac surgery specialists to assess the suitability for bypass surgery, but it was deemed inappropriate.
Therefore, at the beginning of April, one artery was treated with a drug-eluting stent and two bare-metal stents.
After discharge, the original pain in the left chest and left back subsided, but he began to experience pain near the right rib cage.
Three days post-surgery, during a follow-up with the cardiologist, he was informed that this pain was unrelated to the heart and likely associated with the liver.
Consequently, he returned to the hepatobiliary department for evaluation in mid-April, where an ultrasound revealed a liver tumor near the diaphragm, suspected to be the cause of his symptoms.
Both the ultrasound and CT scan indicated no metastasis at this time, but due to the recent stent placement in April, the doctor advised waiting until early May for a follow-up to determine the appropriate treatment for liver cancer (currently leaning towards low-dose immunotherapy).
The current issue is that prior to the stent placement, my father could walk with some shortness of breath but was otherwise mobile.
Since the stent placement, he has gradually become weaker and more fatigued, transitioning from being able to walk independently to experiencing significant weakness in both legs within just a week, requiring support to walk and exhibiting a tendency to lean while walking.
Is this weakness solely due to the cancer? Could it be related to his heart condition or the medications he is taking (currently, he is on hepatitis B medication from the hepatobiliary department, and anticoagulants and lipid-lowering medications from the cardiology department)? Given the rapid onset of his leg weakness, should we consider going to the emergency room or transferring to another specialty for further evaluation? Which specialty would you recommend we consult?

Diane, 40~49 year old female. Ask Date: 2023/04/21

Dr. Huang Yinghe reply Cardiology


Hello: Symptoms of leg weakness generally require ruling out nutritional issues (electrolyte imbalances), medication effects (muscle relaxants, diuretics, psychiatric medications), or other internal medicine conditions (liver or kidney dysfunction, infections), among others.
If the symptoms rapidly worsen, it is advisable to visit the emergency department for an initial evaluation to check for these issues.
If none of these are the cause, consult a neurologist to investigate potential neurological disorders.

Reply Date: 2023/04/21

More Info


Understanding the situation you described regarding your father's post-stent condition involves a multifaceted approach, considering both cardiac and hepatic factors, as well as the potential side effects of medications.
Firstly, it is important to recognize that the placement of stents in the coronary arteries is a significant intervention aimed at restoring blood flow to the heart muscle. While the immediate goal is to alleviate symptoms of coronary artery disease (CAD), such as chest pain and shortness of breath, there can be a range of post-procedural effects.
In your father's case, the initial relief of left chest and back pain suggests that the stenting procedure was successful in addressing the blockage in the coronary arteries. However, the subsequent development of right rib pain and weakness in the legs raises concerns that warrant further investigation.

Potential Causes of Weakness and Pain
1. Medication Side Effects: Post-stent, your father is likely on antiplatelet medications (such as aspirin or clopidogrel) and possibly statins for cholesterol management. While these medications are essential for preventing clot formation and managing cholesterol levels, they can have side effects. For instance, statins are known to cause muscle weakness or pain in some patients. If your father is experiencing significant weakness, it may be worthwhile to discuss his medication regimen with his healthcare provider to assess whether any adjustments are necessary.

2. Cardiac Issues: Although the cardiologist indicated that the rib pain is not related to the heart, it is essential to monitor for any signs of heart failure or other cardiac complications, especially after a significant intervention like stenting. Symptoms such as increasing fatigue, shortness of breath, or swelling in the legs could indicate heart-related issues.

3. Hepatic Concerns: The discovery of a liver tumor raises additional considerations. While the tumor itself may not be causing immediate symptoms, the overall health of the liver can impact physical strength and energy levels. Liver dysfunction can lead to a range of systemic symptoms, including weakness, fatigue, and even changes in mental status.

4. Cancer-Related Fatigue: If the liver tumor is affecting your father's overall health, it could contribute to his feelings of weakness. Cancer and its treatments can lead to significant fatigue, which may manifest as weakness in the limbs.


Recommendations
Given the rapid onset of weakness in your father's legs, it is advisable to seek medical attention promptly. Here are some steps you can take:
- Emergency Evaluation: If your father’s weakness is severe and affects his ability to walk or perform daily activities, it may be prudent to visit the emergency department. This will allow for a comprehensive evaluation to rule out any acute complications related to his heart or liver.

- Follow-Up with Specialists: Depending on the findings from the emergency evaluation, follow-up appointments with both a cardiologist and a hepatologist (liver specialist) may be necessary. They can collaboratively assess whether the symptoms are related to cardiac issues, liver function, or medication side effects.

- Physical Therapy: If weakness is confirmed but no acute issues are found, a referral to physical therapy may help improve strength and mobility.
- Medication Review: Ensure that all medications are reviewed by a healthcare provider to identify any potential side effects that could be contributing to his symptoms.

In conclusion, while the symptoms your father is experiencing could be multifactorial, it is crucial to address them promptly to ensure that any underlying issues are identified and managed appropriately. Regular communication with his healthcare team will be key in navigating this complex situation.

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