Post-Pill Symptoms: Delayed Period After Ella Use - Obstetrics and Gynecology

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Four days after the end of menstruation, I had intercourse and took Ella (ulipristal acetate) the next day as emergency contraception?


The last menstrual period was from March 27 to April 1, lasting a total of 6 days, with cycles typically around 31-33 days.
Intercourse occurred on April 5, and on April 6, Ella (ulipristal acetate) was purchased as an emergency contraceptive.
Currently, on May 2, there are symptoms of breast tenderness and uterine cramping, similar to premenstrual symptoms.
Is this premenstrual syndrome, or could it be something else? The expected menstrual period was around April 27, but it has been delayed by 5-6 days.
Is this delay due to taking the emergency contraceptive?

Rou, 20~29 year old female. Ask Date: 2023/05/02

Dr. Chen Zhiyu reply Obstetrics and Gynecology


Hello, it is recommended to practice safe behaviors to reduce the risk of sexually transmitted infections, while also preventing unintended pregnancies.
Please monitor your menstrual cycle, and if there is a delay, you can take a home pregnancy test or visit an obstetrics and gynecology clinic for confirmation.
Thank you.

Reply Date: 2023/05/02

More Info


The use of emergency contraceptive pills, such as Ella (ulipristal acetate), can indeed lead to changes in menstrual cycles, including delayed periods. In your case, you mentioned that your last menstrual period was from March 27 to April 1, and you had unprotected intercourse on April 5, taking Ella on April 6. Your expected period was around April 27, but as of May 2, you have not yet menstruated and are experiencing symptoms such as breast tenderness and uterine discomfort, which are similar to premenstrual symptoms.

Firstly, it's important to understand how Ella works. Ella is effective in preventing pregnancy primarily by delaying or inhibiting ovulation. It can be taken up to 120 hours (5 days) after unprotected intercourse, and its effectiveness is relatively high, but not 100%. The hormonal changes induced by Ella can affect your menstrual cycle, leading to variations in the timing and characteristics of your next period.

Regarding your symptoms, breast tenderness and uterine discomfort can indeed be indicative of premenstrual syndrome (PMS), but they can also be side effects of the hormonal changes caused by Ella. Many women report experiencing breast tenderness, nausea, fatigue, and changes in their menstrual cycle after taking emergency contraception. These symptoms can mimic those of early pregnancy or premenstrual symptoms, making it challenging to discern the cause without further testing.

The delay in your period could be attributed to the use of Ella. Hormonal contraceptives, including emergency contraceptives, can disrupt the regularity of your menstrual cycle. It's not uncommon for periods to be delayed by a few days to a week after taking Ella. In some cases, women may experience a heavier or lighter period than usual, or their period may come earlier or later than expected.

If your period does not arrive within a week of the expected date, it is advisable to take a pregnancy test to rule out pregnancy. Home pregnancy tests are generally reliable and can provide results as early as the first day of a missed period. If the test is negative and your period still does not come, or if you have any concerns about your symptoms, it would be prudent to consult a healthcare provider for further evaluation.

In summary, the delayed period you are experiencing is likely related to the use of Ella, and the symptoms you are having could be side effects of the medication or premenstrual symptoms. Monitoring your cycle and taking a pregnancy test if your period does not arrive soon will help clarify your situation. If you have any further questions or concerns, do not hesitate to reach out to a healthcare professional for personalized advice and support.

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