Risk of Hepatitis C Infection from Blood Splash: What You Need to Know - Gastroenterology and Hepatology

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Exposure to blood splatter from a patient with hepatitis C?


Hello, doctor.
I am a nursing staff member at a certain hospital.
Today, after performing dialysis on a patient, I accidentally got blood mixed with saline splashed into my eyes while cleaning the equipment.
I can confirm that it was not fresh blood, but rather blood mixed with saline, and the blood had been out of the body for about 10 minutes.
However, that patient is confirmed to have Hepatitis C, with anti-HCV levels exceeding 6000 in the blood drawn within the last two weeks.
I would like to ask: 1.
What is the likelihood of contracting Hepatitis C through blood splashes into the eyes? 2.
If I want to pay out of pocket for HCV RNA testing, how many days after the exposure would you recommend getting tested for the results to be accurate? I am quite anxious about the blood splash incident, and I greatly appreciate your taking the time to respond.

Niming, 20~29 year old female. Ask Date: 2023/05/05

Dr. Chen Shidian reply Gastroenterology and Hepatology


It is recommended to first confirm the patient's viral load (patients with hepatitis C on dialysis have repeatedly been advised by the association to undergo definitive treatment to prevent transmission to others) and notify the infection control physician at your hospital.
Theoretically, there is a possibility of infection, but the likelihood is low.
Generally, liver function should be monitored monthly for 3 to 6 months, and if there is an increase, consideration can be given to testing for viral antibodies and/or viral load.
However, immediate treatment for acute hepatitis C is not recommended, as a high percentage of cases will resolve spontaneously.

Reply Date: 2023/05/05

More Info


Hepatitis C is a viral infection that primarily spreads through blood-to-blood contact. As a healthcare professional, your concern about the risk of infection from exposure to blood, especially in a clinical setting, is completely valid. Let's address your questions regarding the risk of Hepatitis C infection from blood splash and the appropriate follow-up actions.

1. Risk of Infection from Blood Splash to the Eye: The risk of contracting Hepatitis C through exposure to blood splashes in the eye is considered to be low, but it is not zero. Hepatitis C is primarily transmitted through direct blood contact, such as sharing needles or through transfusions of infected blood. In your case, since the blood was mixed with saline and had been outside the body for about 10 minutes, the viral load would likely have decreased significantly. The virus does not survive long outside the human body, especially in a diluted form. However, if the blood contained a high viral load and there was a direct splash into your eye, there is still a theoretical risk of transmission. It is crucial to monitor for any symptoms and consult with an infectious disease specialist for personalized advice.

2. Timing for HCV RNA Testing: If you are considering getting an HCV RNA test, it is generally recommended to wait at least 2 to 4 weeks after potential exposure for the test to be accurate. This is because it can take time for the virus to replicate to detectable levels in the bloodstream. Since you mentioned that the patient had a high anti-HCV level, it suggests that they are actively infected, which increases the importance of monitoring your health. If you experience any symptoms such as fatigue, jaundice, or abdominal pain, you should seek medical attention immediately.

In addition to these points, it is essential to follow standard precautions in healthcare settings to minimize the risk of exposure to bloodborne pathogens. This includes wearing appropriate personal protective equipment (PPE), such as goggles or face shields, when there is a risk of blood splatter, and ensuring that all equipment is properly disposed of or cleaned.

Furthermore, if you have any concerns about your health or potential exposure, it is advisable to consult with your healthcare provider. They may recommend post-exposure prophylaxis or additional testing based on your specific situation.

In summary, while the risk of Hepatitis C transmission from a blood splash to the eye is low, it is not negligible. Monitoring your health and getting tested at the appropriate time are crucial steps. Always prioritize safety measures in your work environment to protect yourself and your patients from potential infections.

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