Blood Pressure Issues: Insights on Medication and Autonomic Dysfunction - Neurology

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Dear Dr.
Tsai,
My mother is 68 years old and has been experiencing blood pressure issues since last year.
Initially, she would feel palpitations, with her blood pressure rising to 200/100 mmHg, accompanied by symptoms such as shortness of breath, instability while standing, fatigue, cold and trembling extremities, and tingling in the scalp.
Due to her high blood pressure, she started taking "Diovan (160 mg)" prescribed by a cardiologist to alleviate her discomfort.
However, during the treatment, she experienced episodes of low blood pressure (around 100/60 mmHg), leading to fatigue and dizziness during the day.
More importantly, the episodes of palpitations and elevated blood pressure (over 200/100 mmHg) continued to occur intermittently, and even taking "Diovan (160 mg)" immediately did not relieve her discomfort.
It wasn't until she had an episode that required an emergency visit, where the doctor prescribed "Labetalol (200 mg)" that her symptoms were immediately alleviated.
Comparing the two medications, the cardiologist mentioned that "Labetalol" has an additional effect of "calming the autonomic nervous system" compared to "Diovan."
I would like to ask Dr.
Tsai the following questions:
Q1.
Based on the effectiveness of the medications, could my mother's elevated blood pressure be attributed to "autonomic nervous system dysfunction" rather than primary hypertension?
Q2.
The prescription label for "Labetalol (200 mg)" states "take as needed." Does this mean that "Labetalol (200 mg)" should not be taken regularly and long-term, or can it be taken regularly and long-term without harming her health?
Thank you, Dr.
Tsai.

Axiang, 40~49 year old female. Ask Date: 2023/05/07

Dr. Cai Zongzhang reply Neurology


Hello: Blood pressure measurements are the basis for hypertension treatment, so it is very important to measure blood pressure correctly.
Blood pressure should be measured after a period of rest, and one should not become anxious about high blood pressure, as this can affect the readings.
There are various antihypertensive medications, and physicians consider many factors when prescribing them.
It is recommended to measure and record blood pressure regularly and accurately.
Each time, these records should be provided to the physician to prescribe the appropriate medication and dosage.

Reply Date: 2023/05/07

More Info


Dear Patient,
Thank you for your detailed inquiry regarding your mother's blood pressure issues and the medications she is currently taking. It’s clear that her symptoms and the medications prescribed have raised some concerns, particularly regarding the role of autonomic dysfunction in her condition. Let’s address your questions one by one.

Q1: Is your mother's high blood pressure due to autonomic dysfunction rather than primary hypertension?
Based on the symptoms you've described, such as palpitations, elevated blood pressure readings, and episodes of dizziness and cold extremities, it is plausible that your mother may be experiencing a form of autonomic dysfunction. Autonomic dysfunction can lead to dysregulation of blood pressure and heart rate, often resulting in episodes of hypertension (high blood pressure) and hypotension (low blood pressure). The fact that her symptoms improve significantly with the use of Labtal (Labetalol) suggests that her condition may be influenced by autonomic factors.
Primary hypertension, which is the most common form of high blood pressure, typically develops gradually over many years and is often related to lifestyle factors, genetics, and other health conditions. In contrast, autonomic dysfunction can lead to more acute fluctuations in blood pressure and heart rate, as seen in your mother’s case. Therefore, it is essential for her healthcare provider to evaluate her autonomic function and consider whether her hypertension is secondary to this dysfunction or if there are other underlying causes.

Q2: Can Labtal (Labetalol) be taken regularly, or is it only for acute episodes?
The labeling on Labtal indicating "as needed" suggests that it is intended for use during episodes of elevated blood pressure or autonomic instability. However, Labetalol is also commonly prescribed for chronic management of hypertension, especially in patients who experience significant fluctuations in blood pressure.
Long-term use of Labetalol is generally considered safe for many patients, but it is crucial to monitor for potential side effects, such as fatigue, dizziness, or hypotension. The decision to use it regularly should be based on a thorough assessment by her healthcare provider, who can evaluate the risks and benefits in her specific case. If your mother finds that her symptoms are better managed with Labtal, it may be appropriate for her to use it regularly, but this should be done under medical supervision.

In conclusion, it is essential for your mother to have regular follow-ups with her healthcare provider to monitor her blood pressure, assess her symptoms, and adjust her medications as necessary. Autonomic dysfunction can be complex, and a tailored approach to her treatment will be crucial in managing her condition effectively.
If you have further questions or concerns, please do not hesitate to reach out. It’s important to ensure that your mother receives the best possible care for her health.

Best regards,
Doctor Q&A Teams

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