Is Temporary Coma Related to Psychiatric Medication Adjustments? - Psychiatry

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Is temporary coma related to adjustments in psychiatric medications?


Hello Doctor: My father (approximately 70 years old) has a history of depression and bipolar disorder.
Earlier this year, he exhibited signs of agitation, and following the doctor's instructions, he began taking 1ml of Depakote and 1ml of Risperidone every night.
After starting the medication, his condition gradually stabilized.
By around April, he began to show a lack of interest in activities, and the doctor adjusted the dosage to 1ml of Depakote and 0.5ml of Risperidone, but there was no improvement.
The doctor noted the emergence of depressive symptoms, so he switched the medication to half a tablet of Lythium in the morning and 2ml of Depakote at night, discontinuing Risperidone.
However, the depression did not improve, and the doctor further adjusted the dosage to one tablet of Lythium in the morning and added one tablet of Bupropion at night along with 2ml of Depakote.
It has been about a week since this adjustment, and there has been no improvement.
More concerning is that he has started experiencing symptoms similar to orthostatic hypotension; whenever he gets up from bed or stands up and then sits down, he experiences trembling in his hands and feet, wide-open eyes, and a brief loss of consciousness for about ten seconds.
The symptoms resemble seizures, but my father has no prior history of seizures and has not suffered any head injuries.
At that moment, his blood pressure readings were around 110 systolic.
Currently, my father can only lie in bed and is afraid to move.
This situation began the day after the medication was changed and has persisted for four days.
I would like to ask the doctor if this condition is related to the medication adjustments.
Do you have any suggestions on how to improve this situation? Thank you very much for taking the time to respond.

Mr. Chen, 70~79 year old female. Ask Date: 2023/05/15

Dr. Xue Gengming reply Psychiatry


Recommendations: 1.
Discuss the above situation further with your attending physician.
2.
Alternatively, consult with other mental health care facilities.
Thank you.
Wishing you good health!

Reply Date: 2023/05/15

More Info


The situation you described regarding your father’s health and medication adjustments is indeed concerning and warrants careful consideration. It is essential to understand that psychiatric medications, particularly those used to treat mood disorders such as depression and bipolar disorder, can have significant effects on a patient’s mental and physical state. Adjustments in medication dosages or types can lead to various side effects, including changes in mood, cognition, and even physical symptoms like the ones you mentioned.


Understanding the Medications
1. Antipsychotics and Mood Stabilizers: Medications like "癲別液" (likely a form of an antipsychotic) and "理斯本" (possibly a mood stabilizer) are commonly prescribed for managing symptoms of bipolar disorder and severe depression. These medications can help stabilize mood but may also lead to side effects, especially during dosage adjustments.

2. SSRIs: The introduction of "離憂" (Escitalopram, an SSRI) is aimed at addressing depressive symptoms. SSRIs can take several weeks to show their full effect, and during this time, patients may experience fluctuations in mood or other side effects.


Potential Side Effects and Concerns
The symptoms you described, such as transient loss of consciousness, shaking, and postural hypotension (a drop in blood pressure upon standing), could potentially be linked to the recent medication adjustments. Here are some considerations:
- Postural Hypotension: This condition can occur when medications, particularly those affecting the central nervous system, alter blood pressure regulation. It is essential to monitor blood pressure regularly, especially after medication changes.

- Transient Coma or Loss of Consciousness: While not typical, some psychiatric medications can cause sedation or altered consciousness, particularly if there is an interaction between multiple medications or if the dosages are too high.

- Withdrawal or Adjustment Symptoms: Stopping or adjusting medications can lead to withdrawal symptoms or a return of depressive symptoms, which may manifest as increased lethargy or disinterest in activities.


Recommendations
1. Immediate Medical Attention: Given the severity of your father's symptoms, it is crucial to consult with his healthcare provider immediately. The symptoms you described, particularly the transient loss of consciousness and shaking, should be evaluated by a physician to rule out any serious complications.

2. Medication Review: A thorough review of all medications your father is taking is necessary. This includes assessing potential interactions between the medications and considering whether the dosages are appropriate for his current condition.

3. Monitoring and Support: Until a healthcare provider can assess your father, ensure he is in a safe environment where he can be monitored. Encourage him to rise slowly from sitting or lying positions to mitigate the risk of falls due to low blood pressure.

4. Communication with Healthcare Providers: Keep an open line of communication with your father’s healthcare team. Document any changes in symptoms, including when they occur and their severity, to provide detailed information during consultations.

5. Consider Non-Pharmacological Interventions: In conjunction with medication, therapies such as cognitive-behavioral therapy (CBT) or supportive counseling can be beneficial in managing mood disorders and may help alleviate some symptoms.


Conclusion
In summary, the changes in your father’s medication regimen could indeed be related to the symptoms he is experiencing. It is vital to seek immediate medical advice to ensure his safety and to adjust his treatment plan as necessary. Mental health management often requires a delicate balance, and close monitoring during medication adjustments is essential to achieving the best outcomes.

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