Does Hyperthyroidism Affect Fasting Blood Sugar Levels? - Internal Medicine

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Does hyperthyroidism affect fasting blood glucose levels?


Hello, doctor! Four years ago, I had my first adult health check-up, and my fasting blood glucose was slightly elevated at 106.
Four years later, I had my second check-up, and my fasting blood glucose is still 106.
Could this unchanged value indicate a possibility of diabetes, or could it be related to my past hyperthyroidism? I was treated for hyperthyroidism several years ago and have been off medication for many years.
Thank you for taking the time to respond!

Yunyu, 40~49 year old female. Ask Date: 2023/05/18

Dr. Li Jian reply Internal Medicine


Thyroid antibody tests should ideally be monitored once a year.
If fasting blood glucose levels are elevated, it is advisable to check glycated hemoglobin (HbA1c) to assess average blood sugar levels.
Thank you for your inquiry.

Reply Date: 2023/05/18

More Info


Hyperthyroidism, or an overactive thyroid, can indeed have an impact on fasting blood sugar levels. This condition is characterized by an excess of thyroid hormones in the body, which can accelerate metabolism and influence various bodily functions, including glucose metabolism.
When the thyroid gland produces too much thyroid hormone, it can lead to increased gluconeogenesis (the production of glucose from non-carbohydrate sources) in the liver, as well as enhanced glycogenolysis (the breakdown of glycogen to glucose). This can result in elevated blood sugar levels, particularly in individuals who may already be predisposed to insulin resistance or impaired glucose tolerance.
In your case, you mentioned that your fasting blood sugar levels have remained consistently at 106 mg/dL over the past four years. According to the American Diabetes Association, a fasting blood sugar level of 100 to 125 mg/dL is classified as "prediabetes," while a level of 126 mg/dL or higher on two separate tests indicates diabetes. Therefore, while your current level of 106 mg/dL does not confirm diabetes, it does place you in the prediabetic range, which warrants monitoring and lifestyle modifications to prevent progression to diabetes.

It is also important to consider your history of hyperthyroidism. If you were diagnosed with hyperthyroidism and have since undergone treatment, it is possible that your thyroid hormone levels have stabilized, but the previous condition could have had lasting effects on your metabolism and glucose regulation. Even after treatment, some individuals may experience lingering effects on their blood sugar levels, particularly if they had significant fluctuations in hormone levels during the period of hyperthyroidism.

To further assess your risk for diabetes, it would be beneficial to monitor not only your fasting blood sugar but also your HbA1c levels, which provide an average blood glucose level over the past two to three months. An HbA1c level of 5.7% to 6.4% indicates prediabetes, while a level of 6.5% or higher suggests diabetes.

In addition to blood tests, lifestyle factors play a crucial role in managing blood sugar levels. Regular physical activity, a balanced diet rich in whole grains, fruits, vegetables, lean proteins, and healthy fats, as well as maintaining a healthy weight, can significantly impact your blood sugar control. Since you have a history of hyperthyroidism, it may also be beneficial to consult with an endocrinologist or a healthcare provider specializing in metabolic disorders to evaluate your thyroid function and its potential impact on your glucose metabolism.

In summary, while your fasting blood sugar levels of 106 mg/dL are concerning and indicate prediabetes, it is essential to consider the potential influence of your past hyperthyroidism. Regular monitoring, lifestyle modifications, and possibly further evaluation of your thyroid function can help you manage your blood sugar levels effectively and reduce the risk of developing diabetes in the future.

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