Loss of Appetite: Causes and Treatment Options - Family Medicine

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Loss of appetite


Hello Doctor, last October I experienced vomiting after staying up all night to catch up on my studies.
Since then, I have had a persistent loss of appetite.
I consulted a gastroenterologist who diagnosed me with gastroesophageal reflux disease (GERD).
After treatment, my appetite slightly improved by the end of the year.
However, about a month ago, due to family pressure to eat, I suddenly felt my heart racing, broke out in a cold sweat, and experienced a wave of nausea.
This has occurred two to three times a week since then, and my weight has dropped from 41 kg to 38 kg.
I have completely lost my appetite and have also started experiencing frequent unilateral tinnitus.
I have always had shallow sleep and difficulty falling asleep, and recently I have had complete insomnia every few days.
I saw a psychiatrist who prescribed me lorazepam 1 mg and vortioxetine HBr 10 mg, advising me to monitor my condition.
However, I am a bit afraid of the side effects of the medication, especially since I have read that many people experience nausea and vomiting from vortioxetine, and my symptoms began with nausea.
This makes me even more anxious and nervous about the side effects.
I would like to ask what disease my symptoms might be related to, or which specialty I should consult to effectively address my condition.
Thank you, Doctor.

W, 20~29 year old female. Ask Date: 2023/05/28

Dr. Lin Zhebin reply Family Medicine


Hello: Based on your description of physical discomfort and the situation regarding medical consultations and prescriptions, it is inferred that you may be experiencing anxiety and depression.
Additionally, it is important to consider the possibility of endocrine disorders, such as hyperthyroidism or diabetes, among others.
Since your symptoms span multiple specialties, it is common to recommend relevant specialties based on your symptoms.
For instance, for nausea and vomiting, a consultation with a gastroenterologist is advised; for rapid heartbeat and cold sweats, a cardiologist should be consulted; for tinnitus, an ear, nose, and throat specialist or a neurologist may be appropriate.
Alternatively, you could start with a visit to a family medicine physician.
Furthermore, it is still recommended that you take the medications prescribed by a psychiatrist, as they may help alleviate your anxiety and depression, which could also improve your physical discomfort.

Reply Date: 2023/05/28

More Info


Loss of appetite can be a complex issue with various underlying causes, and it’s important to approach it holistically. Based on your description, it seems that your loss of appetite and associated symptoms may be linked to a combination of gastrointestinal issues, anxiety, and possibly depression.
Initially, you experienced vomiting after a stressful event, which led to a diagnosis of gastroesophageal reflux disease (GERD). GERD can indeed cause nausea and discomfort, which may contribute to a reduced desire to eat. However, the subsequent episodes of rapid heartbeat, cold sweats, and nausea when pressured to eat suggest that anxiety may be playing a significant role in your current symptoms. This is not uncommon; stress and anxiety can exacerbate gastrointestinal symptoms and lead to a vicious cycle of avoidance and further anxiety.

Your weight loss from 41 kg to 38 kg is concerning, especially if it is unintentional. Significant weight loss can lead to further health complications, including nutritional deficiencies, weakened immune function, and decreased muscle mass. It’s crucial to address both the physical and psychological aspects of your condition.

The medications prescribed to you, lorazepam and vortioxetine, are aimed at managing anxiety and depressive symptoms. Lorazepam is a benzodiazepine that can help with anxiety in the short term, but it is important to use it cautiously due to the potential for dependence and withdrawal symptoms. Vortioxetine, on the other hand, is an antidepressant that can help with both depression and anxiety, but it may cause gastrointestinal side effects, including nausea, especially when starting the medication.

Given your concerns about the side effects of vortioxetine, it’s understandable to feel apprehensive, especially since your symptoms began with nausea. It’s essential to communicate these concerns with your prescribing physician. They may consider adjusting the dosage or switching to a different medication that you might tolerate better.

In terms of treatment options, it would be beneficial to take a multidisciplinary approach. Here are some recommendations:
1. Gastroenterology Follow-Up: Since you have a history of GERD, a follow-up with a gastroenterologist may be warranted. They can assess whether your current symptoms are related to GERD or if there are other gastrointestinal issues at play.

2. Psychiatric Evaluation: Since anxiety and depression can significantly impact appetite and overall well-being, a thorough evaluation by a psychiatrist or psychologist could help. They can provide therapy options, such as cognitive-behavioral therapy (CBT), which has been shown to be effective for anxiety and can help you develop coping strategies.

3. Nutritional Support: Consulting with a registered dietitian may be beneficial. They can help create a meal plan that accommodates your current appetite and nutritional needs, ensuring you receive adequate nutrition even if your intake is limited.

4. Lifestyle Modifications: Incorporating stress-reducing techniques such as mindfulness, meditation, or gentle exercise can help manage anxiety and improve your overall mood. Regular sleep hygiene practices can also aid in improving your sleep quality.

5. Monitoring and Communication: Keep an open line of communication with your healthcare providers about your symptoms and any side effects from medications. Regular monitoring can help adjust treatment plans as needed.

In conclusion, your symptoms may stem from a combination of gastrointestinal issues and anxiety. A comprehensive approach involving gastroenterology, psychiatry, and nutritional support can help address the root causes of your loss of appetite and improve your overall health. It’s crucial to prioritize your well-being and seek support from healthcare professionals who can guide you through this process.

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