Does COVID-19 Vaccination Affect Rapid Test Accuracy? - Influenza

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Does the COVID-19 vaccine affect rapid test results?


Hello Doctor: I received the next-generation vaccine yesterday, and I've been experiencing some throat discomfort in the past few days.
My previous rapid tests were all negative, but today the rapid test came back positive.
I have been in contact with a confirmed case in the past two weeks.
I would like to ask: Is the rapid test result accurate shortly after receiving the vaccine? Or could I have been infected before the vaccination, and does this positive rapid test result indicate a confirmed case?

Niming, 10~19 year old female. Ask Date: 2023/06/02

Dr. Chen Mingong reply Influenza


Hello: After vaccination, the vaccine enters the human bloodstream and lymphatic system, and it does not interfere with or affect the results of rapid tests.
Therefore, a positive result is indeed positive, indicating a confirmed case.
However, individuals who have been vaccinated may experience milder symptoms or may be asymptomatic after a confirmed infection, which is commonly observed in clinical practice.
Therefore, in medical practice, unless an individual experiences severe side effects, we strongly encourage the public to get vaccinated.

Reply Date: 2023/06/02

More Info


COVID-19 vaccination does not affect the accuracy of rapid tests. When you receive a vaccine, it introduces antigens into your body that stimulate your immune system to produce antibodies against the virus. However, this process does not interfere with the mechanisms of rapid antigen tests, which are designed to detect specific proteins from the virus itself, not the antibodies produced in response to vaccination.

In your case, since you have recently received a next-generation vaccine and have been experiencing throat discomfort, it is crucial to consider the timing of your symptoms and the rapid test results. The fact that your previous rapid tests were negative suggests that you may not have been infected at that time. However, the positive result from your most recent test indicates that you likely have an active infection.
It is possible that you were exposed to the virus shortly before or after your vaccination, which could explain the onset of symptoms and the subsequent positive test result. Vaccination can reduce the severity of symptoms and the viral load in vaccinated individuals, but it does not guarantee immunity against infection. Therefore, a positive rapid test result following vaccination is still valid and indicates that you are likely infected with COVID-19.

If you are experiencing symptoms such as throat discomfort, it is advisable to follow up with a PCR test, which is more sensitive and can confirm the presence of the virus. Additionally, it is essential to isolate yourself to prevent further transmission, especially if you have been in contact with confirmed cases.

In summary, the rapid test result you received after vaccination is accurate and indicates a potential COVID-19 infection. It is essential to monitor your symptoms and seek further testing if necessary. Vaccination remains a critical tool in reducing the severity of illness and preventing hospitalizations, but it does not eliminate the risk of infection. Always consult with healthcare professionals for personalized advice and follow local health guidelines regarding testing and isolation.

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